Effects of melatonin and caffeic acid phenethyl ester on testicular injury induced by myocardial ischemia/reperfusion in rats

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dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridEşrefoğlu, Mukaddes/0000-0003-3380-1480
dc.authoridAcet, Ahmet/0000-0003-1131-1878
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidEşrefoğlu, Mukaddes/JWA-4590-2024
dc.authorwosidAcet, Ahmet/AAB-3273-2021
dc.contributor.authorEsrefoglu, M
dc.contributor.authorGül, M
dc.contributor.authorParlakpinar, H
dc.contributor.authorAcet, A
dc.date.accessioned2024-08-04T20:14:46Z
dc.date.available2024-08-04T20:14:46Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractExperimental studies indicate that ischemia/reperfusion (I/R) causes remote organ injury although the molecular mechanism has not been clearly defined. In this report, the role of oxidative injury on testicular damage following myocardial I/R injury and the effects of antioxidant agents, melatonin and caffeic acid phenethyl ester (CAPE), on testicular injury were investigated. As far as we know, this is the first report demonstrating that myocardial I/R induces damage to the testes. Thirty-two male Wistar rats were randomly divided into four groups: sham operation (SO), I/R + vehicle, I/R + melatonin, and I/R + caffeic acid phenethyl ester. To produce cardiac damage, the left main coronary artery was occluded for 30 min, followed by 120 min reperfusion, in anesthetized rats. Serum nitric oxide (NO) and malondialdehyde (MDA) levels and morphological changes were examined. I/R was accompanied by a significant increase in serum MDA and NO levels, whereas, melatonin and CAPE administration significantly reduced these values. Melatonin was more efficient in reducing MDA levels than CAPE (P < 0.05). I/R induced myocardial damage, manifested as the histopathological evidence of intracellular vacuolization, interstitial edema, neutrophil infiltration and coagulative necrosis. I/R + vehicle group showed many histological alterations such as focal tubular atrophy, and degeneration and disorganization of the seminiferous epithelium in testes. The number of atrophic tubules and degenerating cells was significantly higher in I/R + vehicle group than that of SO group. Melatonin and CAPE significantly reduced the number of degenerating cells; additionally, melatonin reduced the number of atrophic tubules (P < 0.05). Our results indicate that myocardial I/R induces severe testicular damage and antioxidant agents, especially melatonin, have protective effects on testicular injury after myocardial I/R. Our data emphasize that oxygen-based reactants may play a central role in remote organ injury.en_US
dc.identifier.doi10.1111/j.1472-8206.2005.00331.x
dc.identifier.endpage372en_US
dc.identifier.issn0767-3981
dc.identifier.issn1472-8206
dc.identifier.issue3en_US
dc.identifier.pmid15910661en_US
dc.identifier.scopus2-s2.0-20044380038en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage365en_US
dc.identifier.urihttps://doi.org/10.1111/j.1472-8206.2005.00331.x
dc.identifier.urihttps://hdl.handle.net/11616/93958
dc.identifier.volume19en_US
dc.identifier.wosWOS:000229584000012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofFundamental & Clinical Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcaffeic acid phenethyl esteren_US
dc.subjectmelatoninen_US
dc.subjectmyocardial ischemia/reperfusionen_US
dc.subjectremote organ injuryen_US
dc.titleEffects of melatonin and caffeic acid phenethyl ester on testicular injury induced by myocardial ischemia/reperfusion in ratsen_US
dc.typeArticleen_US

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