Advanced Hepatocellular Cancer Treated with Sorafenib and Novel Inflammatory Markers

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dc.authoridgülmez, ahmet/0000-0002-3353-344X
dc.authorwosidgülmez, ahmet/ABI-8218-2020
dc.contributor.authorGulmez, Ahmet
dc.contributor.authorHarputluoglu, Hakan
dc.date.accessioned2024-08-04T20:51:39Z
dc.date.available2024-08-04T20:51:39Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective Hepatocellular cancer (HCC) is an aggressive tumor with an increasing incidence in recent years. Life expectancy is limited, especially due to limited effective treatments and tumor biology. In this study, we aimed to examine the effect of neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), prognostic nutritional index (PNI) parameters of treatment efficacy of patients using sorafenib in primary systemic therapy, progression-free survival (PFS), and overall survival (OS). Materials and Methods In this study, we retrospectively analyzed 78 patients who used sorafenib as a first-line systemic treatment. NLR, PLR, and PNI values were calculated with the existing formulas. Cut-off values for these markers were determined by performing ROC curve analysis. These values were determined respectively as 2.88, 111.05, and 38.25. Patients were divided into two groups according to this threshold value. OS and PFS values were calculated using a Cox proportional risk model. The effects of markers on OS and PFS were examined based on the cut-off value. Results The mean PFS was 7.1 (range 1-46) months, and the mean OS was 14.1 (range 1.5-94) months. The pre-treatment decreased NLR (< 2.88) value was prognostic for higher PFS and OS rates. These values were determined respectively as 9.23 +/- 1.79 and 3.45 +/- 0.32 months for PFS and 21.17 +/- 4.53 and 5.32 +/- 0.53 months for OS. Pre-treatment decreased PLR (< 111.05) was found to be a positively significant prognostic value for both survival. These values were determined respectively as 7.37 +/- 1.43 months and 3.16 +/- 0.47 months for PFS and 21.12 +/- 5.52 months and 6.16 +/- 0.87 months for OS. And also, low PNI (< 38.25) value was prognostic for lower PFS and rates. These values were determined respectively as 7.47 +/- 0.59 months and 3.25 +/- 0.21 months for PFS and 16.36 +/- 4.37 months and 5.15 +/- 0.42 for OS. All three parameters were found to be statistically significant (p < 0.05) for both OS and PFS as independent prognostic markers. Conclusion Today, as the standard first-line treatment of HCC has shifted to combinations with immunotherapy (IO), IO transportation is not possible in most countries of the world. However, there are also patients who achieve great survival with only sorafenib. The important point is to identify the biomarkers that predict which patient will benefit better from which treatment. With the markers in our study and a scoring system that can be obtained with these markers, it can be evaluated which patient will be given IO combination and which patient will be given only TKI treatment. We think that such a scoring system can be used to identify suitable patients, especially in countries where, for financial reasons, not every patient can access Immunotherapy. The advantage of these tests is that they are inexpensive, easily calculable and standardized.en_US
dc.identifier.doi10.1007/s12029-021-00789-6
dc.identifier.endpage19en_US
dc.identifier.issn1941-6628
dc.identifier.issn1941-6636
dc.identifier.issue1en_US
dc.identifier.pmid35119620en_US
dc.identifier.scopus2-s2.0-85124207685en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage11en_US
dc.identifier.urihttps://doi.org/10.1007/s12029-021-00789-6
dc.identifier.urihttps://hdl.handle.net/11616/100467
dc.identifier.volume54en_US
dc.identifier.wosWOS:000751250700001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Gastrointestinal Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHepatocellular canceren_US
dc.subjectNeutrophil-to-lymphocyte ratioen_US
dc.subjectPlatelet-to-lymphocyte ratioen_US
dc.subjectPrognostic nutritional indexen_US
dc.titleAdvanced Hepatocellular Cancer Treated with Sorafenib and Novel Inflammatory Markersen_US
dc.typeArticleen_US

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