The effect of apocynin on motor and cognitive functions in experimental Alzheimer's disease

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dc.authoridCigremis, Yilmaz/0000-0002-8600-0946
dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridAkyuva, Yener/0000-0001-8171-5929
dc.authoridKablan, Yüksel/0000-0002-5581-2968
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authorwosidCigremis, Yilmaz/O-6019-2015
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidCigremis, Yilmaz/JAC-8451-2023
dc.authorwosidAkyuva, Yener/AAV-5706-2020
dc.authorwosidKablan, Yüksel/AAB-5049-2021
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.contributor.authorAkyuva, Yener
dc.contributor.authorOnal, Cagatay
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorGul, Mehmet
dc.contributor.authorCigremis, Yilmaz
dc.contributor.authorAtes, Tuncay
dc.contributor.authorKablan, Yuksel
dc.date.accessioned2024-08-04T20:45:21Z
dc.date.available2024-08-04T20:45:21Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractScope: We investigated the potential beneficial effect of Apognin (APO) on motor and cognitive functions in experimental Alzheimer's disease (AD). Materials and Methods: Experimental AD was induced in rats by intraventricular streptozotocin (STZ) injection. Sham group received articial cerebrospinal fiuid (CSF). Both groups were randomly divided into two subgroups. One of the subgroups received intraperitoneal APO for while the other had normal saline (NS). The animals were evaluated with rotarod, accelerod and Water-Maze tests before and after the treatment. Additionally, biochemical markers of oxidative stress such as malondialdehyde (MDA) and reduced glutathione (GSH) were analyzed fiom brain specimens. Standard histological evaluation and transmission electron microscopy (TEM) were used to evaluate the neural damage. Results: The difference between S7Z+NS in comparison with CSF+NS, CSF+APO and STZ+APO were statistically significant on 30 and 40 rpm on rotarod test. GSH levels, accelerod and Water-Maze test results were not statistically significant between subgroups. However, MDA differences between STZ+NS in comparison with CSF+NS, CSF+APO and STZ+APO were statistically significant. Hemotoxikne eozine staining and TEM results showed apocynins protective effect. Conclusion: These results indicate that APO can provide neuro-protective effect for motor but not for cognitive performance in experimental AD.en_US
dc.identifier.doi10.18054/pb.v120i1.5975
dc.identifier.endpage32en_US
dc.identifier.issn0031-5362
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85051199527en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage23en_US
dc.identifier.urihttps://doi.org/10.18054/pb.v120i1.5975
dc.identifier.urihttps://hdl.handle.net/11616/98420
dc.identifier.volume120en_US
dc.identifier.wosWOS:000440027000004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPeriodicum Biologorumen_US
dc.relation.ispartofPeriodicum Biologorumen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectStreptozotocinen_US
dc.subjectApocyninen_US
dc.subjectRotarod testen_US
dc.subjectAccelerod testen_US
dc.subjectWater-Maze testen_US
dc.titleThe effect of apocynin on motor and cognitive functions in experimental Alzheimer's diseaseen_US
dc.typeArticleen_US

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