Effects of ciprofloxacin on fetal rat liver during pregnancy and protective effects of quercetin

dc.authoridTaslidere, Elif/0000-0003-1723-2556
dc.authoridSoysal, Handan/0000-0001-7550-6362
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210;
dc.authorwosidTaslidere, Elif/ABI-8046-2020
dc.authorwosidElbe, Hulya/D-5261-2015
dc.authorwosidDogan, Zumrut yılmaz/V-5131-2018
dc.authorwosidSoysal, Handan/AAL-4660-2020
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.authorwosidDoğan, Zümrüt/GQP-2535-2022
dc.contributor.authorDogan, Z.
dc.contributor.authorElbe, H.
dc.contributor.authorTaslidere, E.
dc.contributor.authorSoysal, H.
dc.contributor.authorCetin, A.
dc.contributor.authorDemirtas, S.
dc.date.accessioned2024-08-04T20:43:58Z
dc.date.available2024-08-04T20:43:58Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractUrinary tract infections are common in pregnant women and ciprofloxacin frequently is used as a broad spectrum antibiotic. It has been suggested that ciprofloxacin causes liver damage in fetuses. Quercetin is a flavonoid with antioxidant properties. We investigated the efficacy of quercetin treatment for preventing fetal liver damage caused by ciprofloxacin. Pregnant rats were divided into four groups: untreated control group (C), 20 mg/kg quercetin for 21 days group (Q), 20 mg/kg twice/day ciprofloxacin for 10 days group (CP), and 20 mg/kg, ciprofloxacin + quercetin for 21 days group (CP + Q). Fetal livers were removed on day 21 of gestation to measure antioxidants and for histological observation. Malondialdehyde (MDA) and glutathione (GSH) levels, and superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities were measured in tissue samples. GSH-Px, SOD and CAT activities were significantly lower in the CP group compared to group C. A significant increase in MDA was observed in the CP group compared to group C. There was no significant difference in GSH levels in any group. MDA levels were lower and CAT, SOD and GSH-Px enzyme activities were higher in the CP + Q group compared to group CP. Liver samples of the CP group exhibited central vein dilation, portal vein congestion, pyknotic nuclei and cytoplasmic vacuolization in some hepatocytes. Histological changes were less prominent in the rats treated with quercetin. Use of ciprofloxacin during pregnancy caused oxidative damage in fetal liver tissue. Oxidative stress was ameliorated by quercetin. Quercetin supports the antioxidant defense mechanism and it is beneficial for treating fetal liver damage caused by ciprofloxacin.en_US
dc.identifier.doi10.1080/10520295.2017.1356469
dc.identifier.endpage486en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue7en_US
dc.identifier.pmid28836867en_US
dc.identifier.scopus2-s2.0-85028530871en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage481en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2017.1356469
dc.identifier.urihttps://hdl.handle.net/11616/97952
dc.identifier.volume92en_US
dc.identifier.wosWOS:000424145900003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectciprofloxacinen_US
dc.subjectfetusen_US
dc.subjectliveren_US
dc.subjectpregnancyen_US
dc.subjectquercetinen_US
dc.subjectraten_US
dc.titleEffects of ciprofloxacin on fetal rat liver during pregnancy and protective effects of quercetinen_US
dc.typeArticleen_US

Dosyalar