Latent Tuberculosis Infection Management in Solid Organ Transplantation Recipients: A National Snapshot

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dc.authoridCinar, Gule/0000-0002-7635-8848
dc.authorwosidCinar, Gule/ABA-2413-2020
dc.contributor.authorAlpaydin, Aylin Ozgen
dc.contributor.authorTurunc, Tuba Yeter
dc.contributor.authorAvkan-Oguz, Vildan
dc.contributor.authorOner-Eyuboglu, Fusun
dc.contributor.authorTukenmez-Tigen, Elif
dc.contributor.authorHasanoglu, Imran
dc.contributor.authorAydin, Gule
dc.date.accessioned2024-08-04T20:56:03Z
dc.date.available2024-08-04T20:56:03Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE: Latent tuberculosis infection (LTBI) screening is strongly recommended in the pre -transplant evaluation of solid organ transplant (SOT) recipients, although it remains inadequate in many transplant centers. We decided to investigate pre -transplant TB risk assessment, LTBI treatment, and registry rates in T & uuml;rkiye. MATERIAL AND METHODS: Adult SOT recipients who underwent tuberculin skin test (TST) and/or interferon -gamma release test (IGRA) from 14 centers between 2015 and 2019 were included in the study. An induration of >= 5 mm on TST and/or probable/positive IGRA (QuantiFERON-TB) was considered positive for LTBI. Demographic features, LTBI screening and treatment, and pre -/post -transplant TB history were recorded from the electronic database of transplantation units across the country and pooled at a single center for a unified database. RESULTS: TST and/or IGRA were performed in 766 (33.8%) of 2266 screened patients most of whom were kidney transplant recipients (n = 485, 63.4%). LTBI screening test was positive in 359 (46.9%) patients, and isoniazid was given to 203 (56.5%) patients. Of the patients treated for LTBI, 112 (55.2%) were registered in the national registry, and 82 (73.2%) completed the treatment. Tuberculosis developed in 6 (1.06%) of 563 patients who were not offered LTBI treatment. CONCLUSION: We determined that overall, only one-third of SOT recipients in our country were evaluated in terms of TB risk, only 1 of the 2 SOT recipients with LTBI received treatment, and half were registered. Therefore, we want to emphasize the critical importance of pretransplant TB risk stratification and registration, guided by revised national guidelines.en_US
dc.identifier.doi10.5152/ThoracResPract.2024.23110
dc.identifier.endpage135en_US
dc.identifier.issn2979-9139
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85194106538en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage130en_US
dc.identifier.urihttps://doi.org/10.5152/ThoracResPract.2024.23110
dc.identifier.urihttps://hdl.handle.net/11616/102012
dc.identifier.volume25en_US
dc.identifier.wosWOS:001243522300005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofThoracic Research and Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSolid organ transplantationen_US
dc.subjecttuberculosisen_US
dc.subjectlatent tuberculosis infectionen_US
dc.subjectinterferon-gamma release testen_US
dc.subjecttuberculin skin testen_US
dc.titleLatent Tuberculosis Infection Management in Solid Organ Transplantation Recipients: A National Snapshoten_US
dc.typeArticleen_US

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