Relationships Between Indices of Tumor Aggressiveness in Hepatocellular Carcinoma

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dc.authoridDonghia, Rossella/0000-0002-9140-673X
dc.authoridCarr, Brian/0000-0002-6111-5077
dc.contributor.authorCarr, Brian I.
dc.contributor.authorGuerra, Vito
dc.contributor.authorDonghia, Rossella
dc.contributor.authorYilmaz, Seai
dc.date.accessioned2024-08-04T20:50:44Z
dc.date.available2024-08-04T20:50:44Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground Hepatocellular carcinoma (HCC) aggressiveness factors include serum levels of alpha-fetoprotein (AFP), maximum tumor diameter (MTD), tumor multifocality, and presence of portal vein thrombosis (PVT). Aims The interdependence of these factors has not been closely studied. Methods A large HCC database was examined for the presence of patients with PVT and multifocality and was analyzed retrospectively for the relationship of these 2 parameters to each other and to MTD and survival. Results Multifocality was found to increase with increase in MTD in the whole cohort and especially in patients with PVT. PVT also increased with increasing MTD. Neither increases in multifocality nor in PVT depended on elevated serum AFP levels, although they each increased with higher AFP levels. PVT increased in monofocal tumors as MTD increased but increased further in multifocal tumors. Conclusions Multifocality and PVT appear to be separate processes, each increasing with increase in MTD and AFP levels. The data support the hypothesis that in hepatocarcinogenesis, various factors cause increase in MTD, that in turn causes increased multifocality and PVT, which are non-co-dependent. However, both multifocality and PVT mechanisms involve both HCC cell growth and invasiveness, multifocality in liver parenchyma, and PVT in the portal vein.en_US
dc.description.sponsorshipNIH [CA 82723]en_US
dc.description.sponsorshipThis work was supported in part by NIH grant CA 82723 (B.I.C).en_US
dc.identifier.doi10.1007/s12029-021-00720-z
dc.identifier.endpage1349en_US
dc.identifier.issn1941-6628
dc.identifier.issn1941-6636
dc.identifier.issue4en_US
dc.identifier.pmid34611834en_US
dc.identifier.scopus2-s2.0-85116488630en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1340en_US
dc.identifier.urihttps://doi.org/10.1007/s12029-021-00720-z
dc.identifier.urihttps://hdl.handle.net/11616/100247
dc.identifier.volume52en_US
dc.identifier.wosWOS:000703826900005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Gastrointestinal Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHCCen_US
dc.subjectFocalityen_US
dc.subjectPVTen_US
dc.subjectSurvivalen_US
dc.subjectRelative risk ratioen_US
dc.titleRelationships Between Indices of Tumor Aggressiveness in Hepatocellular Carcinomaen_US
dc.typeArticleen_US

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