Determination of pKa values of some novel benzimidazole salts by using a new approach with 1H NMR spectroscopy

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dc.authoridKUCUKBAY, HASAN/0000-0002-7180-9486;
dc.authorwosidKUCUKBAY, HASAN/A-5050-2019
dc.authorwosidmumcu, akın/ABG-9283-2020
dc.contributor.authorMumcu, Akin
dc.contributor.authorKucukbay, Hasan
dc.date.accessioned2024-08-04T20:41:27Z
dc.date.available2024-08-04T20:41:27Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBenzimidazoles and their derivatives including imidazole are studied widely because they exist in the structure of natural products and different drugs. pK(a) values are extremely important for drug discovery and improvement in order to determine pharmacokinetic and pharmacodynamic features such as permeation through biological barriers, interactions with the target area or side effects. Acid-base features (pK(a)) have great importance not only for physiological characteristics but also for being used as a ligand or changing physico-chemical features by turning benzimidazoles into salts. Within the scope of this study, a variety of new benzimidazole salts were synthesized, and their characterizations were made by NMR spectroscopy, FTIR spectroscopy and element analysis techniques. The pK(a) values of synthesized benzimidazole saltswere determined by inflection point approach using integration values obtained with H-1 NMR spectroscopy and Henderson-Hasselbalch analysis. pK(a) values of some benzimidazole salts were also determined by potentiometric methods in order to compare those of NMR spectroscopy results. Copyright (C) (C) 2015 John Wiley & Sons, Ltd.en_US
dc.description.sponsorshipInonu University [BAPB-2011/137]en_US
dc.description.sponsorshipWe wish to thank Inonu University Research Fund (BAPB-2011/137) for its financial support of this study. We also thank Associate Prof. F. Zehra Kucukbay for her helpful discussion and advice during the potentiometric titration works.en_US
dc.identifier.doi10.1002/mrc.4294
dc.identifier.endpage1030en_US
dc.identifier.issn0749-1581
dc.identifier.issn1097-458X
dc.identifier.issue12en_US
dc.identifier.pmid26256272en_US
dc.identifier.scopus2-s2.0-84955178404en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1024en_US
dc.identifier.urihttps://doi.org/10.1002/mrc.4294
dc.identifier.urihttps://hdl.handle.net/11616/97132
dc.identifier.volume53en_US
dc.identifier.wosWOS:000365383400004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofMagnetic Resonance in Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbenzimidazole derivativesen_US
dc.subjectdetermination of pK(a)en_US
dc.subjectH-1 NMR spectroscopyen_US
dc.subjectpotentiometric titrationen_US
dc.titleDetermination of pKa values of some novel benzimidazole salts by using a new approach with 1H NMR spectroscopyen_US
dc.typeArticleen_US

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