Changes in nitric oxide levels and antioxidant enzyme activities may have a role in the pathophysiological mechanisms involved in autism

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dc.authoridOZYURT, Huseyin/0000-0003-2327-4082
dc.authoridYanik, Medaim/0000-0001-5936-0017
dc.authorwosidKAPLAN, MEHMET/AAA-9808-2020
dc.authorwosidOZYURT, Huseyin/N-4351-2015
dc.authorwosidzoroglu, suleyman s/B-2077-2012
dc.authorwosid, mehmet/AAG-6430-2020
dc.authorwosidZoroglu, Salih/ABD-8029-2020
dc.contributor.authorSögüt, S
dc.contributor.authorZoroglu, SS
dc.contributor.authorÖzyurt, H
dc.contributor.authorYilmaz, HR
dc.contributor.authorÖzugurlu, F
dc.contributor.authorSivasli, E
dc.contributor.authorYetkin, Ö
dc.date.accessioned2024-08-04T20:13:45Z
dc.date.available2024-08-04T20:13:45Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: There is evidence that oxygen free radicals play an important role in the pathophysiology of many neuropsychiatric disorders. Although it has not been investigated yet, several recent studies proposed that nitric oxide (NO) and other parameters related to oxidative stress may have a pathophysiological role in autism. Methods: We assessed the changes in superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activities and thiobarbituric acid-reactive substances (TBARS) levels in plasma as well as NO levels in red blood cells (RBC) in patients with autism (n = 27) compared to age- and sex-matched normal controls (n = 30). Results: In the autistic group, increased RBC NO levels (p < 0.0001) and plasma GSH-Px activity (p < 0.0001) and unchanged plasma TBARS levels and SOD activity were detected. Conclusions: These findings indicate a possible role of increased oxidative stress and altered enzymatic antioxidants, both of which may be relevant to the pathophysiology of autism. (C) 2003 Published by Elsevier Science B.V.en_US
dc.identifier.doi10.1016/S0009-8981(03)00119-0
dc.identifier.endpage117en_US
dc.identifier.issn0009-8981
dc.identifier.issue1-2en_US
dc.identifier.pmid12691871en_US
dc.identifier.scopus2-s2.0-12444304256en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage111en_US
dc.identifier.urihttps://doi.org/10.1016/S0009-8981(03)00119-0
dc.identifier.urihttps://hdl.handle.net/11616/93798
dc.identifier.volume331en_US
dc.identifier.wosWOS:000182507200015en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofClinica Chimica Actaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectautismen_US
dc.subjectthiobarbituric acid-reactive substances (TBARS)en_US
dc.subjectsuperoxide dismutase (SOD)en_US
dc.subjectglutathione peroxidase (GSH-Px)en_US
dc.subjectnitric oxide (NO)en_US
dc.titleChanges in nitric oxide levels and antioxidant enzyme activities may have a role in the pathophysiological mechanisms involved in autismen_US
dc.typeArticleen_US

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