Prognostic value of inflammatory markers determined during diagnosis in patients with sarcoidosis: chronic versus remission

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dc.authoridGungor, Sinem/0000-0002-1163-125X
dc.authoridtuncay, Eylem Acarturk/0000-0002-5046-1943
dc.authoridYalçınsoy, Murat/0000-0003-3407-7359
dc.authoridTokgoz Akyil, Fatma/0000-0002-3793-9834
dc.authorwosidGungor, Sinem/GPX-1807-2022
dc.authorwosidtuncay, Eylem Acarturk/GPX-1832-2022
dc.authorwosidYalçınsoy, Murat/ABI-1421-2020
dc.contributor.authorBekir, Sumeyye Alparslan
dc.contributor.authorYalcinsoy, Murat
dc.contributor.authorGungor, Sinem
dc.contributor.authorTuncay, Eylem
dc.contributor.authorAkyil, Fatma Tokgoz
dc.contributor.authorSucu, Pakize
dc.contributor.authorYavuz, Dilek
dc.date.accessioned2024-08-04T20:50:56Z
dc.date.available2024-08-04T20:50:56Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE: This study aimed to evaluate the prognostic value of inflammatory markers determined during admission among patients with sarcoidosis with chronic and remission groups. METHODS: This study was designed as retrospective single-center study. Patients with sarcoidosis without treatment and who had at least two years of follow-up were included in this study. Patients were divided into two groups as chronic and remission. The primary outcome is to evaluate hematological parameters in remission and chronic sarcoidosis groups. RESULTS: Out of 348 patients with sarcoidosis, 142 patients without treatment and followed up for at least two years were included in this study. Groups had similar demographic features with the predominance of females (80.4 and 77.9%, respectively) and stage I disease (78.6 and 68.6%, respectively). Lymphocyte count [median (IQR) 1.7 (1.3-2.3) 109/L versus 2.1 (1.6-2.4) 109/L, p=0.034] was significantly lower, whereas neutrophil to lymphocyte ratio (NLR) was significantly higher [median (IQR) 2.6 (2.0-3.1) versus 2.0 (1.6-2.8), p=0.006] at admission in the chronic group. No significant difference was determined in inflammatory parameters at admission between groups. CONCLUSION: Lower lymphocyte count and higher neutrophil to lymphocyte ratio were determined in patients with chronic sarcoidosis compared with the remission group, based on monitoring of radiological staging up to five-year after the initial diagnosis. Accordingly, the identification of neutrophil to lymphocyte ratio at diagnosis seems to be a potential prognostic marker in patients with sarcoidosis beside its low cost and easy determination in routine clinical practice.en_US
dc.identifier.doi10.1590/1806-9282.20210627
dc.identifier.endpage1580en_US
dc.identifier.issn1806-9282
dc.identifier.issue11en_US
dc.identifier.pmid34909881en_US
dc.identifier.scopus2-s2.0-85121557556en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1575en_US
dc.identifier.urihttps://doi.org/10.1590/1806-9282.20210627
dc.identifier.urihttps://hdl.handle.net/11616/100374
dc.identifier.volume67en_US
dc.identifier.wosWOS:000731423100012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAssoc Medica Brasileiraen_US
dc.relation.ispartofRevista Da Associacao Medica Brasileiraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSarcoidosisen_US
dc.subjectChronic granulomatous diseaseen_US
dc.subjectPrognosisen_US
dc.titlePrognostic value of inflammatory markers determined during diagnosis in patients with sarcoidosis: chronic versus remissionen_US
dc.typeArticleen_US

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