The expression levels of genes involved in JNK signalingdecrease by aging in the liver

Basit Öğe Kaydı
dc.contributor.authorKaraca, Zeynal
dc.contributor.authorKaraca, Gamze
dc.contributor.authorKayhan, Basak
dc.contributor.authorKuştepe, Elif Kayhan
dc.date.accessioned2024-08-04T19:42:46Z
dc.date.available2024-08-04T19:42:46Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: The c-Jun NH2-terminal kinases (JNK) signaling pathway is an important signaling pathway in liver regeneration. it was planned to investigate the expression levels of Mitogen Activated Protein Kinase Kinase (MKK)-4 and -7 (MKK7), which are mediator molecules involved in the JNK signaling pathway and Activating Transcription Factor (ATF) 2 transcription factor genes, which are in the last stage of the signaling pathway, in liver tissues in young and old mice. In addition, it was aimed to examine the ultrastructural changes caused by aging in hepatocytes. Material and Methods: We examined MKK4, MKK7 and ATF2 expression levels by using Real Time Polymerase Chain Reaction (RT-qPCR) method. Transmission electron microscopy (TEM) was used to observe the ultrastructural changes of hepatocytes. Results: While MKK4 and ATF2 gene expressions reduced in the liver of aged mice, MKK7 gene expression did not change. In TEM examinations, granular endoplasmic reticulum loss and mitochondrial damage were observed in elderly individuals. Conclusion: According to these results, spontaneous liver damage that can be seen in aged subjects may be caused by disruption in cellular signaling pathways and organelle damage in hepatocytes.en_US
dc.identifier.endpage362en_US
dc.identifier.issn2636-7688
dc.identifier.issue4en_US
dc.identifier.startpage357en_US
dc.identifier.trdizinid517888en_US
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/517888
dc.identifier.urihttps://hdl.handle.net/11616/88662
dc.identifier.volume29en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofAnnals of Medical Researchen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe expression levels of genes involved in JNK signalingdecrease by aging in the liveren_US
dc.typeArticleen_US

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