The beneficial effects of Montelukast against 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity in female reproductive system in rats

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dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoridMELEKOGLU, RAUF/0000-0001-7113-6691
dc.authoridCelik, ebru/0000-0002-0774-4294
dc.authoridbasak, nese/0000-0001-5566-8321
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.authorwosidMELEKOGLU, RAUF/AAF-1614-2019
dc.authorwosidCelik, ebru/X-4343-2019
dc.authorwosidbasak, nese/ABH-5495-2020
dc.contributor.authorMelekoglu, Rauf
dc.contributor.authorCiftci, Osman
dc.contributor.authorCetin, Ash
dc.contributor.authorBasak, Nese
dc.contributor.authorCelik, Ebru
dc.date.accessioned2024-08-04T20:42:41Z
dc.date.available2024-08-04T20:42:41Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPURPOSE: To determine the toxic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on reproductive system and the beneficial effects of Montelukast (ML) with histological and biochemical analysis. METHODS: Rats were randomly divided into four equal groups (control, TCDD, ML and TCDD+ML). Tissue samples were collected on day 60 and oxidative status and histological alterations were analyzed. RESULTS: The results showed a significant increase in oxidative and histological damage on uterine and ovarian tissues. Otherwise, the oxidative and histological damages caused by TCDD were prevented with ML treatment. CONCLUSION: The toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on female reproductive system were reversed with Montelukast treatment. Therefore, we claimed that ML treatment might be useful for TCDD toxicity.en_US
dc.identifier.doi10.1590/S0102-865020160080000009
dc.identifier.endpage563en_US
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.issue8en_US
dc.identifier.pmid27579884en_US
dc.identifier.scopus2-s2.0-84985998580en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage557en_US
dc.identifier.urihttps://doi.org/10.1590/S0102-865020160080000009
dc.identifier.urihttps://hdl.handle.net/11616/97496
dc.identifier.volume31en_US
dc.identifier.wosWOS:000383883900009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherActa Cirurgica Brasileiraen_US
dc.relation.ispartofActa Cirurgica Brasileiraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTetrachlorodibenzodioxinen_US
dc.subjectOxidative Stressen_US
dc.subjectLeukotriene Antagonistsen_US
dc.subjectOvaryen_US
dc.subjectUterusen_US
dc.titleThe beneficial effects of Montelukast against 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity in female reproductive system in ratsen_US
dc.typeArticleen_US

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