The Molecular Mechanism of the Effect of Carvacrol on Desflurane Inhalation-Induced Liver Damage in Rats

Basit Öğe Kaydı
dc.authoridTaş, Hakan Gökalp/0000-0001-5680-9544;
dc.authorwosidTaş, Hakan Gökalp/HHD-2030-2022
dc.authorwosidYAZICI, GÜLCE/GYR-3499-2022
dc.contributor.authorDisli, Zeliha Korkmaz
dc.contributor.authorDelen, Leman Acun
dc.contributor.authorTas, Hakan Gokalp
dc.contributor.authorKuyrukluyildiz, Ufuk
dc.contributor.authorDisli, Olcay Murat
dc.contributor.authorYazici, Gulce Naz
dc.contributor.authorCoban, Abdulkadir
dc.date.accessioned2024-08-04T20:51:48Z
dc.date.available2024-08-04T20:51:48Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe metabolite of desflurane has been linked to hepatotoxicity. Carvacrol possesses antioxidant, antibacterial, antifungal, anticancer, anti-inflammatory, and spasmolytic properties, according to research. Our goal is to demonstrate that carvacrol protects rats' livers against repeated doses of desflurane. Healthy (HG), desflurane (DS), and carvacrol + desflurane treatment (CDS) groups were formed from 18 albino male Wistar rats. A single dosage of carvacrol and 6% desflurane was given for 2 h on the 0th and 8th days. In the CDS group, the ALT and AST, MDA, TOS, NF-xB, TNF-alpha IL1 beta levels were lower compared to the DS group (p < 0.001). The tGSH,TAS levels were found to be higher in the CDS group compared to the DS group (p < 0.001). It was determined that the mean degeneration level, Kupffer cell activation and PMNL infiltration were found to be lower compared to the DS group (p < 0.05).We confirmed that carvacol can be used in the treatment of desflurane-related liver injury.en_US
dc.identifier.endpage137en_US
dc.identifier.issn0326-2383
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85127149965en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage130en_US
dc.identifier.urihttps://hdl.handle.net/11616/100563
dc.identifier.volume41en_US
dc.identifier.wosWOS:000747919200002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherColegio Farmaceuticos Provincia De Buenos Airesen_US
dc.relation.ispartofLatin American Journal of Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantioxidanten_US
dc.subjectcarvacrolen_US
dc.subjectdesfluraneen_US
dc.subjecthepatotoxicityen_US
dc.subjectinhalation anesthesiaen_US
dc.titleThe Molecular Mechanism of the Effect of Carvacrol on Desflurane Inhalation-Induced Liver Damage in Ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu