Spot analyses of serum neopterin, tryptophan and kynurenine levels in a random group of blood donor population

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dc.authorscopusid26024440900
dc.authorscopusid12786931400
dc.authorscopusid35722850100
dc.authorscopusid55826329800
dc.authorscopusid7004401160
dc.authorscopusid7005240098
dc.authorscopusid6602831648
dc.contributor.authorÜnüvar S.
dc.contributor.authorGirgin G.
dc.contributor.authorPalabiyik S.S.
dc.contributor.authorKaraagac T.
dc.contributor.authorÖzcebe O.I.
dc.contributor.authorSahinc G.
dc.contributor.authorBaydar T.
dc.date.accessioned2024-08-04T19:59:34Z
dc.date.available2024-08-04T19:59:34Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn transfusions, safety measures are used for the health of both receivers and donors. In this regard, early and sensitive markers are strongly needed. The aim of this study was to evaluate neopterin profile and tryptophan degradation in a group of Turkish blood donors. The effect of age, gender, blood type and Rh factor were also assessed. Neopterin was measured by ELISA kits. Serum tryptophan and kynurenine were determined by high performance liquid chromatography. Kynurenine/tryptophan (kyn/ trp) was calculated to estimate tryptophan degradation. Tryptophan, kynurenine and kyn/trp levels were found to be higher in males compared with females (all p < 0.05). Neopterin and kynurenine levels tended to increase with age in age subgroups (all p < 0.05). On the contrary, smoking, Rh factor and blood types were all observed to have no effect on measured parameters (all p ? 0.05). In routine analysis, early and reliable biomarkers are needed. In parallel with current markers, neopterin can be used to select safe donors and to maintain the safety of transfusion. In the face of our results, we recommend that donations with neopterin levels above 19 nmol/L should be excluded from the program because increased neopterin levels indicate activation of the cellular immune system. © 2013 Walter de Gruyter GmbH, Berlin/Boston.en_US
dc.identifier.doi10.1515/pterid-2013-0013
dc.identifier.endpage46en_US
dc.identifier.issn0933-4807
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84882302141en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage41en_US
dc.identifier.urihttps://doi.org/10.1515/pterid-2013-0013
dc.identifier.urihttps://hdl.handle.net/11616/90731
dc.identifier.volume24en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWalter de Gruyter GmbHen_US
dc.relation.ispartofPteridinesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject3-dioxigenaseen_US
dc.subjectBlood banken_US
dc.subjectIndoleamine-2en_US
dc.subjectKynurenineen_US
dc.subjectNeopterinen_US
dc.subjectTryptophanen_US
dc.titleSpot analyses of serum neopterin, tryptophan and kynurenine levels in a random group of blood donor populationen_US
dc.typeArticleen_US

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