Effect of COVID-19 Pandemic on Patients Who Have Undergone Liver Transplantation: Retrospective Cohort Study

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dc.authoridÇOLAK, CEMİL/0000-0001-5406-098X
dc.authoridSarıtaş, Serdar/0000-0003-4076-9001
dc.authoridAkbulut, Sami/0000-0002-6864-7711
dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridSARICI, KEMAL BARIŞ/0000-0001-9595-1906
dc.authoridGARZALI, IBRAHIM UMAR/0000-0002-9797-851X
dc.authoridYagin, Fatma Hilal/0000-0002-9848-7958
dc.authorwosidÇOLAK, CEMİL/ABI-3261-2020
dc.authorwosidSarıtaş, Serdar/ABG-8413-2020
dc.authorwosidAkbulut, Sami/L-9568-2014
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.authorwosidSARICI, KEMAL BARIŞ/ABI-4356-2020
dc.authorwosidGARZALI, IBRAHIM UMAR/ITU-1475-2023
dc.authorwosidYagin, Fatma Hilal/ABI-8066-2020
dc.contributor.authorAkbulut, Sami
dc.contributor.authorYagin, Fatma Hilal
dc.contributor.authorSahin, Tevfik Tolga
dc.contributor.authorGarzali, Ibrahim Umar
dc.contributor.authorTuncer, Adem
dc.contributor.authorAkyuz, Musap
dc.contributor.authorBagci, Nazlican
dc.date.accessioned2024-08-04T20:54:31Z
dc.date.available2024-08-04T20:54:31Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: In liver transplant (LT) recipients, immunosuppressive therapy may potentially increase the risk of severe COVID-19 and may increase the mortality in patients. However, studies have shown conflicting results, with various studies reporting poor outcomes while the others show no difference between the LT recipients and healthy population. The aim of this study is to determine the impact of the COVID-19 pandemic on survival of LT recipients. Methods: This is a retrospective cohort study analyzing the data from 387 LT recipients diagnosed with COVID-19. LT recipients were divided into two groups: survival (n = 359) and non-survival (n = 28) groups. A logistic regression model was used to determine the independent risk factors for mortality. Machine learning models were used to analyze the contribution of independent variables to the mortality in LT recipients. Results: The COVID-19-related mortality rate in LT recipients was 7.2%. Multivariate analysis showed that everolimus use (p = 0.012; OR = 6.2), need for intubation (p = 0.001; OR = 38.4) and discontinuation of immunosuppressive therapy (p = 0.047; OR = 7.3) were independent risk factors for mortality. Furthermore, COVID-19 vaccination reduced the risk of mortality by 100 fold and was the single independent factor determining the survival of the LT recipients. Conclusion: The effect of COVID-19 infection on LT recipients is slightly different from the effect of the disease on the general population. The COVID-19-related mortality is lower than the general population and vaccination for COVID-19 significantly reduces the risk of mortality.en_US
dc.identifier.doi10.3390/jcm12134466
dc.identifier.issn2077-0383
dc.identifier.issue13en_US
dc.identifier.pmid37445501en_US
dc.identifier.scopus2-s2.0-85165049523en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/jcm12134466
dc.identifier.urihttps://hdl.handle.net/11616/101471
dc.identifier.volume12en_US
dc.identifier.wosWOS:001028302000001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofJournal of Clinical Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVID-19 pandemicen_US
dc.subjectliver transplantationen_US
dc.subjectimmunosuppressive agentsen_US
dc.subjectCOVID-19 vaccineen_US
dc.titleEffect of COVID-19 Pandemic on Patients Who Have Undergone Liver Transplantation: Retrospective Cohort Studyen_US
dc.typeArticleen_US

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