Out-of-Reference Range Thyroid-Stimulating Hormone Levels in Levothyroxine-Treated Primary Hypothyroid Patients: A Multicenter Observational Study

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dc.authoridSahin, Ibrahim/0000-0002-6231-0034
dc.authoridUYGUR, Meliha Melin/0000-0002-6569-8142
dc.authoridGogas Yavuz, Dilek/0000-0002-0075-6313
dc.authoridSarac, Zeliha Fulden/0000-0001-9281-2492
dc.authorwosidSahin, Ibrahim/ABI-6050-2020
dc.authorwosiddikbaş, oğuz/GQP-2024-2022
dc.authorwosidSarac, Fulden/AAA-9040-2021
dc.authorwosidUYGUR, Meliha Melin/AAJ-5766-2021
dc.authorwosidYalın, Serap/L-7402-2017
dc.authorwosidGogas Yavuz, Dilek/GRR-7277-2022
dc.authorwosidŞahin, İbrahim/HHY-8303-2022
dc.contributor.authorYavuz, Dilek Gogas
dc.contributor.authorYazici, Dilek
dc.contributor.authorKeskin, Lezzan
dc.contributor.authorAtmaca, Aysegul
dc.contributor.authorSancak, Seda
dc.contributor.authorSarac, Fulden
dc.contributor.authorSahin, Ibrahim
dc.date.accessioned2024-08-04T20:44:00Z
dc.date.available2024-08-04T20:44:00Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Although levothyroxine (LT4) replacement therapy for hypothyroidism has been established as safe, inexpensive and effective, many studies from different countries reported out-of-reference range thyroid-stimulating hormone (TSH) values for the hypothyroid patients under LT4 treatment. The aim of this study was to determine TSH levels of primary hypothyroid patients under LT4 treatment and to assess self-reported compliance with daily LT4 intake in tertiary care centers in Turkey. Design: In this cross-sectional, observational study, adult patients with primary hypothyroidism, receiving LT4 treatment for at least 6 months, were included. The patients were from 12 tertiary care centers in 9 cities of Turkey. TSH and free T4 levels were recorded from patient files and self-reported compliance with daily LT4 intake was assessed by interviewing the subjects at the last visit. Results: A total of 1,755 subjects (46 +/- 13 years; F/M: 89.9/10.1%) with primary hypothyroidism were enrolled. Of the hypothyroid subjects, 44.8% had out-of-reference range serum TSH levels. TSH values were over the reference range (TSH > 4 mIU/L) in 26.2% and were under the reference range (TSH < 0.5 mIU/L) in 18.6% of the patients. Total duration of LT4 treatment was 5.9 +/- 4.7 years and mean dose was 1.2 +/- 0.6 mu g/kg/day. Non-compliant patients (31.1%) had higher TSH levels (6.9 +/- 16 vs 3.8 +/- 0.9 mIU/L, P = 0.01) compared to compliant patients. Conclusion: The results of this study revealed that nearly half of the hypothyroid patients had out-of-reference range serum TSH values, despite under LT4 treatment. Compliance with LT4 treatment seems to be one of the major determinants to reach the target TSH levels in hypothyroid patients.en_US
dc.identifier.doi10.3389/fendo.2017.00215
dc.identifier.issn1664-2392
dc.identifier.pmid28955301en_US
dc.identifier.scopus2-s2.0-85029714553en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3389/fendo.2017.00215
dc.identifier.urihttps://hdl.handle.net/11616/97977
dc.identifier.volume8en_US
dc.identifier.wosWOS:000410277300001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherFrontiers Media Saen_US
dc.relation.ispartofFrontiers in Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecthypothyroidismen_US
dc.subjectlevothyroxineen_US
dc.subjecttarget thyroid-stimulating hormoneen_US
dc.subjectthyroid-stimulating hormoneen_US
dc.subjectprimary hypothyroidismen_US
dc.subjectcomplianceen_US
dc.titleOut-of-Reference Range Thyroid-Stimulating Hormone Levels in Levothyroxine-Treated Primary Hypothyroid Patients: A Multicenter Observational Studyen_US
dc.typeArticleen_US

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