Association of low maternal levels of salusins with gestational diabetes mellitus and with small-for-gestational-age fetuses

Basit Öğe Kaydı
dc.authoridCelik, ebru/0000-0002-0774-4294
dc.authoridKaraer, Abdullah/0000-0002-2010-6211
dc.authoridTURKCUOGLU, ILGIN/0000-0002-8342-1956
dc.authorwosidCelik, ebru/X-4343-2019
dc.authorwosidKaraer, Abdullah/ABI-4667-2020
dc.contributor.authorCelik, Ebru
dc.contributor.authorCelik, Onder
dc.contributor.authorYilmaz, Ercan
dc.contributor.authorTurkcuoglu, Ilgin
dc.contributor.authorKaraer, Abdullah
dc.contributor.authorTurhan, Ugur
dc.contributor.authorAydin, Suleyman
dc.date.accessioned2024-08-04T20:37:26Z
dc.date.available2024-08-04T20:37:26Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: To evaluate maternal and cord serum concentrations of salusin-alpha and salusin-beta in women with gestational diabetes mellitus (GDM) and with small-for-gestational age (SGA) fetuses. Study design: Pregnant women with GDM (n = 25), women with SGA (n = 20) and maternal age-matched normal healthy pregnant subjects (n = 25) participated in the study. Maternal serum and cord blood salusin-alpha and salusin-beta levels at the time of birth were measured using ELISA, and their relation with metabolic parameters was also assessed. Results: Mean concentrations of maternal and fetal serum salusin-alpha in the GDM and SGA groups were significantly lower than those of the controls (P < 0.001, P < 0.001, P < 0.001 and P < 0.001, respectively). Mean concentrations of maternal and cord blood salusin-beta also decreased in both the GDM and the SGA groups in comparison to the control group (P < 0.001, P < 0.001, P < 0.001 and P < 0.001, respectively). The concentrations of maternal serum salusin-alpha and salusin-beta were strongly positively correlated with the concentrations of cord blood salusin-alpha and salusin-beta (R = 0.92, P < 0.001 and R = 0.94, P < 0.001, respectively). Conclusions: The low levels of maternal serum salusin-alpha and salusin-beta may have negative impact on metabolic disorders and vascular dysfunction. (C) 2012 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ejogrb.2012.10.032
dc.identifier.endpage33en_US
dc.identifier.issn0301-2115
dc.identifier.issn1872-7654
dc.identifier.issue1en_US
dc.identifier.pmid23178004en_US
dc.identifier.scopus2-s2.0-84874512106en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage29en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejogrb.2012.10.032
dc.identifier.urihttps://hdl.handle.net/11616/95970
dc.identifier.volume167en_US
dc.identifier.wosWOS:000316429200006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofEuropean Journal of Obstetrics & Gynecology and Reproductive Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGestational diabetes mellitusen_US
dc.subjectSmall-for-gestational ageen_US
dc.subjectCord blooden_US
dc.subjectSalusin-alphaen_US
dc.subjectSalusin-betaen_US
dc.subjectHOMA-IRen_US
dc.titleAssociation of low maternal levels of salusins with gestational diabetes mellitus and with small-for-gestational-age fetusesen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu