Oxidative stress in otosclerosis

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dc.authoridEnsari, Nuray/0000-0002-3373-9173
dc.authoridMUMBUÇ, LÜTFI SEMIH/0000-0003-4977-2581
dc.authoriddurucu, cengiz/0000-0001-7607-6421
dc.authoridKanlikama, Muzaffer/0000-0002-3537-7778
dc.authoridTAYSI, Seyithan/0000-0003-1251-3148
dc.authorwosidEnsari, Nuray/AAC-9791-2020
dc.authorwosidMUMBUÇ, LÜTFI SEMIH/AAG-9421-2020
dc.authorwosiddurucu, cengiz/HNR-2511-2023
dc.authorwosidbaysal, elif/AAH-6406-2019
dc.authorwosidKanlikama, Muzaffer/AAG-8311-2020
dc.authorwosidTAYSI, Seyithan/G-6398-2019
dc.contributor.authorBaysal, Elif
dc.contributor.authorGulsen, Secaattin
dc.contributor.authorAytac, Ismail
dc.contributor.authorCelenk, Fatih
dc.contributor.authorEnsari, Nuray
dc.contributor.authorTaysi, Seyithan
dc.contributor.authorBinici, Habib
dc.date.accessioned2024-08-04T20:42:31Z
dc.date.available2024-08-04T20:42:31Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: Otosclerosis is a disease involving abnormal bone turnover in the human otic capsule that results in hearing loss. Several hypotheses have been suggested for the etiopathogenesis of otosclerosis; however, its etiology remains unclear. Methods: This study evaluated the correlation between otosclerosis and levels of paraoxonase-1 (PON1), arylesterase, total antioxidant status, total oxidant status (TOS), oxidative stress index (OSI), total sulfhydryl (-SH) groups, lipid hydroperoxide, and ceruloplasmin in the serum of otosclerosis patients and healthy subjects with respect to oxidative stress. Results: In our study, TOS and OSI levels were higher in the otosclerosis patients than in the controls. The PON1 levels showed that oxidative stress was severe, and as a result, antioxidants were consumed and depleted. Discussion: When an imbalance between oxygen free radical production and antioxidative defense mechanisms occurs, reactive oxygen species levels may increase, which in turn may damage cells and tissues through the peroxidation of phospholipid membrane structures. The body initially responds with increased antioxidant production, but if the oxidative stress is severe, decreased antioxidant levels may result. This study reports expression levels of oxidative stress species in otosclerosis patients.en_US
dc.identifier.doi10.1080/13510002.2016.1207920
dc.identifier.endpage239en_US
dc.identifier.issn1351-0002
dc.identifier.issn1743-2928
dc.identifier.issue5en_US
dc.identifier.pmid27387094en_US
dc.identifier.scopus2-s2.0-84978531185en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage235en_US
dc.identifier.urihttps://doi.org/10.1080/13510002.2016.1207920
dc.identifier.urihttps://hdl.handle.net/11616/97415
dc.identifier.volume22en_US
dc.identifier.wosWOS:000406474200006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofRedox Reporten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOxidative stressen_US
dc.subjectOtosclerosisen_US
dc.titleOxidative stress in otosclerosisen_US
dc.typeArticleen_US

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