The investigation of serum levels of ADAMTS 5 and 8 (the A disintegrin and metalloproteinase with thrombospondin motifs) in the etiology of endometrial cancer

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dc.authoridMELEKOGLU, RAUF/0000-0001-7113-6691
dc.authoridTOPRAK, SERHAT/0000-0003-4136-0523
dc.authoridTaskapan, Mehmet Cagatay/0000-0002-5273-4909
dc.authoridOLMEZ, FATMA/0000-0003-4196-9224
dc.authorwosidMELEKOGLU, RAUF/AAF-1614-2019
dc.authorwosidTOPRAK, Serhat/ABI-5367-2020
dc.authorwosidTOPRAK, SERHAT/AAD-7854-2021
dc.authorwosidTaskapan, Mehmet Cagatay/ABI-7747-2020
dc.authorwosidYILMAZ, Ercan/AAA-1818-2021
dc.contributor.authorYilmaz, Ercan
dc.contributor.authorMelekoglu, Rauf
dc.contributor.authorTaskapan, Cagatay
dc.contributor.authorBudak, Fatma Olmez
dc.contributor.authorToprak, Serhat
dc.date.accessioned2024-08-04T20:46:58Z
dc.date.available2024-08-04T20:46:58Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the serum levels of the A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) 5 and 8 in patients diagnosed with endometrial cancer. Our study included 41 patients diagnosed with endometrial cancer. The control group consisted of 41 patients diagnosed with benign endometrial pathology. The serum samples were centrifuged and stored at -80 degrees C. The serum levels of ADAMTS were significantly higher (p<.001), whereas the levels of ADAMTS 8 were significantly lower in patients diagnosed with cancer (p<.001). In addition to the presence of known factors in the aetiology of endometrial cancer, the effect of inflammatory factors and some new proteins has centred on the causes of tumourigenesis in recent years. In this sense, these proteins, called the ADAMTS, are the source of new studies.Impact Statement What is already known on this subject? When the recent studies about endometrial cancer are evaluated, it is seen that the effects of chronic inflammation and cytokines have gained importance in its aetiology. The A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) gene family consist of 19 proteases that play essential role in the formation of the extracellular matrix (ECM) and interact with inflammatory cytokines. These proteases and their substrates provide a wide range of functions in different tissues, including ECM remodelling, angiogenesis, fibrosis and coagulation. What the results of this study add? ADAMTS 5, which causes the degradation of the ECM with Aggrecanase activity, was found to be significantly higher in patients diagnosed with cancer and ADAMTS 8 with anti-angiogenesis activity was significantly lower in patients diagnosed with endometrial cancer.en_US
dc.identifier.doi10.1080/01443615.2019.1674265
dc.identifier.endpage859en_US
dc.identifier.issn0144-3615
dc.identifier.issn1364-6893
dc.identifier.issue6en_US
dc.identifier.pmid31782329en_US
dc.identifier.scopus2-s2.0-85075745310en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage856en_US
dc.identifier.urihttps://doi.org/10.1080/01443615.2019.1674265
dc.identifier.urihttps://hdl.handle.net/11616/99077
dc.identifier.volume40en_US
dc.identifier.wosWOS:000499748300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal of Obstetrics and Gynaecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectADAMTS5en_US
dc.subjectADAMTS8en_US
dc.subjectendometrial canceren_US
dc.subjecttumourigenesisen_US
dc.subjectchronic inflammationen_US
dc.titleThe investigation of serum levels of ADAMTS 5 and 8 (the A disintegrin and metalloproteinase with thrombospondin motifs) in the etiology of endometrial canceren_US
dc.typeArticleen_US

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