New sulfa drug derivatives and their zinc(II) complexes: synthesis, spectroscopic properties and in vitro cytotoxic activities

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dc.authoridKeskin, Tuba/0000-0002-9212-4021
dc.authorwosidöz, samet/HKO-7583-2023
dc.authorwosidŞAHAL, HAKAN/JDN-1557-2023
dc.authorwosidKeskin, Tuba/AGX-8609-2022
dc.contributor.authorSahal, Hakan
dc.contributor.authorOz, Samet
dc.contributor.authorKeskin, Tuba
dc.contributor.authorTekin, Suat
dc.contributor.authorCanpolat, Erdal
dc.contributor.authorKaya, Mehmet
dc.date.accessioned2024-08-04T20:53:35Z
dc.date.available2024-08-04T20:53:35Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractSynthesis of four sulfa drug derivatives (L-1-L-4) and Zn(II) complexes derived from sulfonamide group antibiotic substances was carried out using the hydrothermal technique (HT) and their structures of the obtained compounds were explained using elemental analysis (EA), FT-IR and NMR (H-1- and C-13-). Cytotoxic activities of four novel sulfa drug based-Schiff base compounds and their Zn(II) complexes were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay using MCF-7 (human breast cancer), Caco-2 (human colorectal adenocarcinoma), A2780 (human ovarian cancer) and LNCaP (human prostate adenocarcinoma) cell lines. LogIC50 values of all obtained compounds were computed with the Graphpad Prism 6 program after 24 h of treatment for MCF-7, Caco-2, A2780 and LNCaP cells. Comet assay experiments were performed using LogIC(50) concentrations of all compounds to determine DNA damage. Based on the data obtained, all compounds significantly decreased MCF-7, Caco-2, A2780 and LNCaP cell viability compared to the control groups (p < 0.05). Communicated by Ramaswamy H. Sarmaen_US
dc.identifier.doi10.1080/07391102.2023.2192803
dc.identifier.endpage147en_US
dc.identifier.issn0739-1102
dc.identifier.issn1538-0254
dc.identifier.issue1en_US
dc.identifier.pmid36974943en_US
dc.identifier.scopus2-s2.0-85151958090en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage134en_US
dc.identifier.urihttps://doi.org/10.1080/07391102.2023.2192803
dc.identifier.urihttps://hdl.handle.net/11616/101279
dc.identifier.volume42en_US
dc.identifier.wosWOS:000956687100001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal of Biomolecular Structure & Dynamicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSulfonamide antibioticsen_US
dc.subjectSchiff baseen_US
dc.subjectZn(II) complexen_US
dc.subjectcancer cell linesen_US
dc.subjectcytotoxic activityen_US
dc.titleNew sulfa drug derivatives and their zinc(II) complexes: synthesis, spectroscopic properties and in vitro cytotoxic activitiesen_US
dc.typeArticleen_US

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