The Effect of Methylprednisolone on Facial Nerve Paralysis With Different Etiologies

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dc.authoridKARLIDAG, turgut/0000-0003-2748-7309
dc.authoridKaygusuz, İrfan/0000-0002-5237-2362
dc.authoridYALCIN, SINASI/0000-0002-6528-9234
dc.authoridKeleş, Erol/0000-0003-4443-6714
dc.authoridAKPOLAT, Nusret/0000-0002-9138-2117
dc.authorwosidKARLIDAG, turgut/W-7266-2018
dc.authorwosidKaygusuz, İrfan/W-1486-2018
dc.authorwosidAkyigit, Abdulvahap/W-2984-2018
dc.authorwosidYALCIN, SINASI/W-7128-2018
dc.authorwosidKeleş, Erol/W-7207-2018
dc.authorwosidAKPOLAT, Nusret/ABF-6986-2020
dc.contributor.authorYildirim, Mehmet Akif
dc.contributor.authorKarlidag, Turgut
dc.contributor.authorAkpolat, Nusret
dc.contributor.authorKaygusuz, Irfan
dc.contributor.authorKeles, Erol
dc.contributor.authorYalcin, Sinasi
dc.contributor.authorAkyigit, Abdulvahap
dc.date.accessioned2024-08-04T20:41:26Z
dc.date.available2024-08-04T20:41:26Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: The objective of this study was to evaluate the effectiveness of methylprednisolone (MP) in models of facial nerve paralysis obtained by nerve section, compression, or inoculation with herpes simplex virus (HSV). Study Design: Experimental controlled animal study. Setting: Tertiary referral center. Methods: A total of 30 female New Zealand rabbits weighing 1200-3000 g were used for the study. They were randomly assigned to one of 6 groups of 5 animals each. A nerve section injury was realized in Groups 1a (section and MP) and 1b (section, control) rabbits. A compression-type injury was inflicted to rabbits in Groups 2a (compression and MP) and 2b (compression, control). As for animals in Groups 3a (Type 1 HSV and MP) and 3b (Type 1 HSV, controls), facial nerve paralysis resulting from viral infection was obtained. Animals in the 3 treatment groups, designated with the letter a'', were administered MP, 1mg/kg/d, whereas those in control groups b'' received 1mL normal saline, both during 3 weeks. All subjects were followed up for 2 months. At the end of this period, all animals had the buccal branch of the facial nerve excised on the operated side. Semi-thin sections of these specimens were evaluated under light microscopy for the following: perineural fibrosis, increase in collagen fibers, myelin degeneration, axonal degeneration, Schwann cell proliferation, and edema. Results: No significant difference was observed (P> 0.05) between theMP treatment group and the control group with regard to perineural fibrosis, increase in collagen fibers, myelin degeneration, axonal degeneration, edema, or Schwann cell proliferation. In the group with a compressive lesion (Group 2), controls were no different from MP-treated animals as to perineural fibrosis, increase in collagen fibers, or Schwann cell proliferation, whereas axonal degeneration, myelin degeneration, and edema were significantly higher (P< 0.05) in the control group. When comparing the treatment and control groups among the animals inoculated with Type 1HSV, no significant difference was found with regard to perineural fibrosis, axonal degeneration, myelin degeneration, or Schwann cell proliferation. The only statistically significant advantage of the treatment group was in edema formation (P< 0.05). Conclusions: As a result of the evaluation of MP efficacy in different models of facial nerve palsy, we may say that this drug was without effect on nerve healing in paralysis due to nerve section and that it only reduced nervous edema in paralysis induced by Type 1 HSV, whereas it had positive effects on healing in the type of paralysis caused by nerve compression.en_US
dc.identifier.doi10.1097/SCS.0000000000001502
dc.identifier.endpage815en_US
dc.identifier.issn1049-2275
dc.identifier.issn1536-3732
dc.identifier.issue3en_US
dc.identifier.pmid25933144en_US
dc.identifier.scopus2-s2.0-84953342308en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage810en_US
dc.identifier.urihttps://doi.org/10.1097/SCS.0000000000001502
dc.identifier.urihttps://hdl.handle.net/11616/97101
dc.identifier.volume26en_US
dc.identifier.wosWOS:000355236700080en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal of Craniofacial Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFacial nerve palsyen_US
dc.subjectherpes simplex virus Type 1en_US
dc.subjectMPen_US
dc.titleThe Effect of Methylprednisolone on Facial Nerve Paralysis With Different Etiologiesen_US
dc.typeArticleen_US

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