Comparison of Antioxidant Effects of Isoflurane and Propofol in Patients Undergoing Donor Hepatectomy

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dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridToprak, Hüseyin İlksen/0000-0001-9293-8116
dc.authoridOZGUL, Ulku/0000-0003-3738-1751
dc.authoridaydogan, mustafa said/0000-0002-7106-1156
dc.authoridUçar, Muharrem/0000-0002-1232-9829
dc.authoridErsoy, Mehmet/0000-0002-0724-2825
dc.authoridErdogan, Mehmet Ali/0000-0002-3860-6919
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.authorwosidToprak, Hüseyin İlksen/AAN-4023-2020
dc.authorwosidDurmuş, Mahmut/AAG-3377-2019
dc.authorwosidOZGUL, Ulku/ABI-6823-2020
dc.authorwosidaydogan, mustafa said/AAA-2828-2021
dc.authorwosidUçar, Muharrem/ABH-7761-2020
dc.authorwosidErdogan, Mehmet Ali/ABI-7224-2020
dc.contributor.authorUcar, M.
dc.contributor.authorOzgul, U.
dc.contributor.authorPolat, A.
dc.contributor.authorToprak, H. I.
dc.contributor.authorErdogan, M. A.
dc.contributor.authorAydogan, M. S.
dc.contributor.authorDurmus, M.
dc.date.accessioned2024-08-04T20:40:08Z
dc.date.available2024-08-04T20:40:08Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground. The safety of healthy volunteer donors is one of the most important issues in living-donor liver transplantation. Use of the Pringle maneuver during donor hepatectomy can result in liver ischemia-reperfusion (IR) injury. The objective of this study was to examine the effects of isoflurane and propofol on IR injury caused by the Pringle maneuver during donor hepatectomy. Methods. A total of 70 American Society of Anesthesiology I-II donors aged 18-65 years who underwent hepatectomy were included in the study. The patients were randomly divided into 2 groups: propofol and isoflurane. Plasma superoxide dismutase (SOD), malondialdehyde (MDA), total oxidative status (TOS), total antioxidant capacity (TAC), and oxidative stress index (OSI) were measured before surgery (to) and after surgery (t(1)). Results. There were no statistically significant differences in demographic features, anesthesia, and times of surgery between the groups (P > .05). Plasma TAC levels at to and t(1) were significantly lower in the propofol group than in the isoflurane group (P < .05). OSI at t(1) was significantly higher in the propofol group than in the isoflurane group (P < .05). MDA levels were significantly higher in the propofol group than in the isoflurane group at to (P < .05). MDA levels level were significantly higher in the isoflurane group than in the propofol group at t(1) (P < .05). Conclusions. Propofol may have protective effects against IR injury caused by the Pringle maneuver during donor hepatectomy in living-donor transplantations. However, the effectiveness of propofol for clinical use needs to be investigated further.en_US
dc.identifier.doi10.1016/j.transproceed.2014.11.043
dc.identifier.endpage472en_US
dc.identifier.issn0041-1345
dc.identifier.issn1873-2623
dc.identifier.issue2en_US
dc.identifier.pmid25769593en_US
dc.identifier.scopus2-s2.0-84926156694en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage469en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2014.11.043
dc.identifier.urihttps://hdl.handle.net/11616/96731
dc.identifier.volume47en_US
dc.identifier.wosWOS:000351480600040en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIncreased Oxidative Stressen_US
dc.titleComparison of Antioxidant Effects of Isoflurane and Propofol in Patients Undergoing Donor Hepatectomyen_US
dc.typeArticleen_US

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