Effects of Quercetin on Cisplatin-Induced Renal Damage in Wistar Albino Rats

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dc.authoridÇetinavcı, Dilan/0000-0002-4148-7711
dc.authoridTaslidere, Elif/0000-0003-1723-2556
dc.authoridCETIN, Asli/0000-0003-3902-3210
dc.authorwosidÇetinavcı, Dilan/AAB-1849-2022
dc.authorwosidTaslidere, Elif/ABI-8046-2020
dc.contributor.authorCetinavci, Dilan
dc.contributor.authorElbe, Hulya
dc.contributor.authorTaslidere, Elif
dc.contributor.authorBostancieri, Nuray
dc.contributor.authorTaslidere, Asli
dc.date.accessioned2024-08-04T20:10:36Z
dc.date.available2024-08-04T20:10:36Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: Cisplatin is one of the effective antineoplastic drugs widely used in the treatment of many types of cancer. Cisplatin has harmful effects such as nephrotoxicity, ototoxicity and cardiomyopathy. Quercetin is an antioxidant of the flavonoid group. In this study, it was aimed to investigate the therapeutic effects of quercetin against cisplatin-induced kidney damage in rats. Materials and Methods: Twenty-eight male Wistar albino rats were randomly selected and divided into 4 groups: Group 1: Control (no application), Group 2: Quercetin (25 mg/kg/7 days/intraperitoneal), Group 3: Cisplatin (7 mg/kg/single dose/ intraperitoneal), Group 4: Cisplatin+quercetin (7 mg) /kg/single dose/ intraperitoneal cisplatin followed by 25 mg/kg/7 days/ intraperitoneal quercetin). After routine histological follow-up, hematoxylin eosin and periodic acid-schiff staining were performed. Histopathological damage score was calculated. Caspase-3 immunostaining was performed and scored. Results: Control and quercetin groups had normal histological appearance. In the cisplatin group, dilatation of the tubules, epithelial shedding, vacuolization of the tubular epithelial cells, and loss of microvilli in the proximal tubules were detected. In addition, infiltration areas were also found in places. In addition, an increase in caspase-3 immunostaining intensity was detected in this group (p=0.000). Histopathological findings were significantly reduced in the cisplatin+quercetin group compared to the cisplatin group (p=0.001). Conclusion: In this study, we think that quercetin is histopathologically beneficial in the treatment of cisplatin-induced kidney damage.en_US
dc.identifier.doi10.4274/nkmj.galenos.2022.24865
dc.identifier.endpage224en_US
dc.identifier.issn2587-0262
dc.identifier.issue2en_US
dc.identifier.startpage219en_US
dc.identifier.trdizinid1129374en_US
dc.identifier.urihttps://doi.org/10.4274/nkmj.galenos.2022.24865
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1129374
dc.identifier.urihttps://hdl.handle.net/11616/92893
dc.identifier.volume10en_US
dc.identifier.wosWOS:001207572200017en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofNamik Kemal Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCisplatinen_US
dc.subjectquercetinen_US
dc.subjectcaspase-3en_US
dc.subjectkidney toxicityen_US
dc.subjectapoptosisen_US
dc.titleEffects of Quercetin on Cisplatin-Induced Renal Damage in Wistar Albino Ratsen_US
dc.typeArticleen_US

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