Schiff base poloxamer P85 combination prevents prostate cancer progression in C57 Bl6 mice

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dc.authoridTR103979en_US
dc.authoridTR43945en_US
dc.authoridTR34170en_US
dc.authoridTR109036en_US
dc.authoridTR51440en_US
dc.authoridTR204822en_US
dc.authoridTR40558en_US
dc.authoridTR122982en_US
dc.authoridTR13440en_US
dc.contributor.authorDoğan, Ayşegül
dc.contributor.authorDemirci, Selami
dc.contributor.authorBaşak, Neşe
dc.contributor.authorÇağlayan, Ahmet Burak
dc.contributor.authorAydın, Safa
dc.contributor.authorTelci, Dilek
dc.contributor.authorKılıç, Ertuğrul
dc.contributor.authorŞahin, Kazım
dc.contributor.authorOrhan, Cemal
dc.contributor.authorTuzcu, Mehmet
dc.contributor.authorŞahin, Fikrettin
dc.contributor.authorDoğan Ekinci, Işın Asiye
dc.date.accessioned2017-04-17T11:27:33Z
dc.date.available2017-04-17T11:27:33Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBACKGROUND. Prostate cancer which is the second most common cause of death among men has a high incidence in recent years. Current therapeutic regimens should be improved to overcome drug resistance. At the metastatic stage, tumors become refractory to established chemotherapeutic treatments and cause serious problems at the clinics. Development of new drug molecules that are able to transport through the membrane easily and kill tumor cells rapidly is of great interest. METHOD. In the current study, a novel Heterodinuclear copper(II)Mn(II) Schiff base complex combined with P85 was used for prostate cancer treatment in vivo. Tramp-C1 cells injected animals were subjected to chemotherapeutic formulation treatment and results were analyzed by toxicology analysis, tumor volume measurements, and histopathological analysis. 0.5 mg/kg Schiff base was selected and combined with 0.05% P85 according to the toxicology analysis showing the enzyme levels, blood parameters, and multiple organ toxicity. RESULTS. Results demonstrated that Heterodinuclear copper(II)Mn(II) complex-P85 combination decreased tumor formation and tumor volume steadily over the course of experiments. CONCLUSIONS. Overall, Heterodinuclear copper(II)Mn(II) complex-P85 exerted remarkable anti-cancer activity in vivo in C57/B16 mice. Prostate 76:1454–1463, 2016. # 2016 Wiley Periodicals, Inc.en_US
dc.identifier.citationDoğan, A. Demirci, S. Başak, N. Çağlayan, A. B. Aydın, S.Telci, D. Kılıç, E. Şahin, K. Orhan, C. Tuzcu, M. Şahin, F. Doğan Ekinci, I. A. (2016). Schiff Base Poloxamer P85 Combination Prevents Prostate Cancer Progression in C57 Bl6 Mice . Prostate, 76:1454–1463.en_US
dc.identifier.doi10.1002/pros.23229en_US
dc.identifier.endpage1463en_US
dc.identifier.startpage1454en_US
dc.identifier.urihttps://hdl.handle.net/11616/6674
dc.identifier.volume76en_US
dc.language.isoenen_US
dc.publisherProstateen_US
dc.relation.ispartofProstateen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSchiff baseen_US
dc.subjectPluronicen_US
dc.subjectP85en_US
dc.subjectProstate canceren_US
dc.subjectTrampen_US
dc.subjectC1en_US
dc.titleSchiff base poloxamer P85 combination prevents prostate cancer progression in C57 Bl6 miceen_US
dc.typeArticleen_US

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