Investigation of the Relationship Between IL-17, IL-27, IL-2 Blood Levels in Spontaneous Abortion and Healthy Pregnant Women

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dc.contributor.authorOzbey, Gurkan
dc.contributor.authorTanriverdi, Elif Seren
dc.contributor.authorCakir, Ayberk
dc.contributor.authorYilmaz, Ercan
dc.date.accessioned2026-04-04T13:31:01Z
dc.date.available2026-04-04T13:31:01Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractBackground: Cytokines are essential for regulating immune cell activity during pregnancy. Research shows that CD4+ T-cells exhibit specific cytokine secretion patterns, resulting in polarized immune responses. This study aims to compare the gene expression levels of Th1, Th2, and Th17 cytokines in women with normal pregnancies versus those with a history of recurrent spontaneous abortion (RSA). Methods: In this case-control study, 20 patients with RSA within 24 h of their last abortion were compared to 20 pregnant women with no history of abortion (Control Group). Cytokine levels of IL-2, IL-17, and IL-27 were quantified using real-time polymerase chain reaction (RT-PCR). Results: Overall cytokine levels were similar between the groups, but the cytokine levels in both groups were generally similar. However, higher IL-17 and IL-2 levels were observed in the healthy pregnancy group (p = 0.006 and p = 0.001, respectively). Elevated IL-17 and IL-27 levels were observed in healthy pregnancies, whereas lower levels were seen shortly after a miscarriage. IL-27 levels were significantly higher in women with recurrent abortions compared to those with healthy pregnancies (p < 0.001). Conclusions: Elevated IL-2 levels may be a risk factor for RSA. Consistent with recent studies, our findings emphasize the role of IL-17 and IL-27 as crucial regulatory cytokines for maintaining a successful pregnancy.
dc.identifier.doi10.3390/life15030326
dc.identifier.issn2075-1729
dc.identifier.issue3
dc.identifier.orcid0000-0001-7961-0087
dc.identifier.orcid0000-0002-0449-0356
dc.identifier.orcid0000-0001-5749-4556
dc.identifier.pmid40141672
dc.identifier.scopus2-s2.0-105001352131
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/life15030326
dc.identifier.urihttps://hdl.handle.net/11616/108532
dc.identifier.volume15
dc.identifier.wosWOS:001454081200001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofLife-Basel
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectThl cell
dc.subjectTh2 cell
dc.subjectpregnancy
dc.subjectIL-2
dc.subjectIL-17
dc.subjectspontaneous abortion
dc.titleInvestigation of the Relationship Between IL-17, IL-27, IL-2 Blood Levels in Spontaneous Abortion and Healthy Pregnant Women
dc.typeArticle

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