Adrenomedullin and nitrite levels in children with minimal change nephrotic syndrome

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dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridBalat, Ayse/0000-0002-8904-1348
dc.authoridKutlu, Nurettin Onur/0000-0002-3306-6570
dc.authoridYologlu, Saim/0000-0002-9619-3462
dc.authoridYurekli, Muhittin/0000-0002-5830-8564
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidcekmen, mustafa baki/G-6122-2011
dc.authorwosidBalat, Ayse/JOZ-8426-2023
dc.authorwosidKutlu, Nurettin Onur/AAW-6196-2021
dc.authorwosidYologlu, Saim/ABI-8014-2020
dc.authorwosidYurekli, Muhittin/B-4414-2016
dc.contributor.authorBalat, A
dc.contributor.authorÇekmen, M
dc.contributor.authorYürekli, M
dc.contributor.authorGülcan, H
dc.contributor.authorKutlu, O
dc.contributor.authorTürköz, Y
dc.contributor.authorYologlu, S
dc.date.accessioned2024-08-04T20:12:07Z
dc.date.available2024-08-04T20:12:07Z
dc.date.issued2000
dc.departmentİnönü Üniversitesien_US
dc.description.abstractNitric oxide (NO) serves many functions within the kidney, and recent evidence suggests that NO contributes to glomerular injury. Adrenomedullin (AM) is a novel hypotensive peptide originally isolated from human pheochromocytoma. Recent studies showed that plasma AM concentrations correlated with the extent of proteinuria. We have examined the possible role of these two agents by studying plasma and urinary total nitrite (NO-(2) + NO-(3)) and AM levels in children with minimal change nephrotic syndrome (MCNS). In comparison with healthy controls, children with MCNS had increased urinary nitrite excretion (mu mol/mg urinary creatinine), irrespective of whether the disease was in relapse or remission (3.2+/-0.2 in relapse, n=13; 1.9+/-0.3 in remission, n=12; 1.0+/-0.2 in controls, n=10, P<0.05). Plasma nitrite levels (mol/l) were high in relapse compared with controls (53.2+/-8.7 vs 32+/-4.0, P<0.05). Plasma AM levels (pmol/ml) were decreased in relapse (27.6+/-1.4 in relapse, 43.3+/-1.2 in remission, 41.5+/-1.6 in controls, P<0.05). Urinary AM levels (pmol/mg urinary creatinine) were significantly higher in relapse than in remission and in controls (156+/-43 in relapse, 56+/-18 in remission, 36+/-16 in controls, P<0.05). Our data indicate that NO may play a role in mediating the clinical manifestations of MCNS in children. However, changes in AM levels may be the result of heavy proteinuria.en_US
dc.identifier.doi10.1007/s004670000440
dc.identifier.endpage73en_US
dc.identifier.issn0931-041X
dc.identifier.issue1-2en_US
dc.identifier.pmid11095016en_US
dc.identifier.scopus2-s2.0-0033671606en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage70en_US
dc.identifier.urihttps://doi.org/10.1007/s004670000440
dc.identifier.urihttps://hdl.handle.net/11616/93215
dc.identifier.volume15en_US
dc.identifier.wosWOS:000090145800018en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer-Verlagen_US
dc.relation.ispartofPediatric Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadrenomedullinen_US
dc.subjectminimal change nephrotic syndromeen_US
dc.subjectnitric oxideen_US
dc.titleAdrenomedullin and nitrite levels in children with minimal change nephrotic syndromeen_US
dc.typeArticleen_US

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