Protective and therapeutic effects of dexpanthenol on isoproterenol-induced cardiac damage in rats
dc.authorid | Tanriverdi, Lokman Hekim/0000-0003-4263-5234 | |
dc.authorid | Parlakpınar, Hakan/0000-0001-9497-3468 | |
dc.authorid | Taşlidere, Aslı Cetin/0000-0003-3902-3210 | |
dc.authorid | Acet, Ahmet/0000-0003-1131-1878 | |
dc.authorid | Polat, Alaadin/0000-0002-6920-3856 | |
dc.authorid | Ozhan, Onural/0000-0001-9018-7849 | |
dc.authorid | Parlakpinar, Hakan/0000-0001-9497-3468 | |
dc.authorwosid | Tanriverdi, Lokman Hekim/M-5701-2015 | |
dc.authorwosid | Parlakpınar, Hakan/T-6517-2018 | |
dc.authorwosid | Taşlidere, Aslı Cetin/AAB-3979-2021 | |
dc.authorwosid | Acet, Ahmet/AAB-3273-2021 | |
dc.authorwosid | Polat, Alaadin/AAA-7171-2021 | |
dc.authorwosid | Ozhan, Onural/AAE-2356-2020 | |
dc.authorwosid | Parlakpinar, Hakan/V-6637-2019 | |
dc.contributor.author | Kalkan, Ferhat | |
dc.contributor.author | Parlakpinar, Hakan | |
dc.contributor.author | Disli, Olcay M. | |
dc.contributor.author | Tanriverdi, Lokman H. | |
dc.contributor.author | Ozhan, Onural | |
dc.contributor.author | Polat, Alaaddin | |
dc.contributor.author | Cetin, Asli | |
dc.date.accessioned | 2024-08-04T20:45:25Z | |
dc.date.available | 2024-08-04T20:45:25Z | |
dc.date.issued | 2018 | |
dc.department | İnönü Üniversitesi | en_US |
dc.description.abstract | The purpose of the study was to explore the protective and therapeutic effects of dexpanthenol (DEX) on isoproterenol (ISO)-induced cardiac damage. Forty rats were distributed into four groups: group I (Control); group II (ISO); ISO (150mg/kg/day) was given to rats once a day for 2 consecutive days with an interval of 24h; group III (DEX+ISO): DEX (250mg/kg) was applied 30min before the first ISO administration and continued in the next two days after second ISO administration; group IV (ISO+DEX): After the ISO treatment at 1st and 2nd days, DEX was given at 3rd and 4th days. Rats were monitored for mean arterial blood pressure (BP), heart rate, oxygen saturation (%SO2), and electrocardiography (ECG). Heart tissue levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), reduced glutathione (GSH), total oxidant status (TOS); total antioxidant capacity (TAC), oxidative stress index (OSI), and caspase-3 were determined. BP and SO2 values indicated a significant decrease in the ISO group. Also, T wave negativity was observed in 6 of 10 rats, SOD, CAT, and GPX levels were significantly lower in ISO group than control group. ISO administration increased TOS and OSI levels, whereas DEX treatment significantly reduced these parameters. Also, ISO-induced morphological alterations such as disorganization of cardiomyocytes, loss of myofibrils and cytoplasmic vacuolization whereas these histological damages were significantly decreased in ISO+DEX and DEX+ISO groups when compared to the ISO group. This study implies the cardioprotective effects of DEX on ISO-induced cardiotoxicity. | en_US |
dc.description.sponsorship | Scientific and Technological Research Council of Turkey [2209/A-2012] | en_US |
dc.description.sponsorship | The Scientific and Technological Research Council of Turkey, Grant number: 2209/A-2012 | en_US |
dc.identifier.doi | 10.1002/jcb.27058 | |
dc.identifier.endpage | 7489 | en_US |
dc.identifier.issn | 0730-2312 | |
dc.identifier.issn | 1097-4644 | |
dc.identifier.issue | 9 | en_US |
dc.identifier.pmid | 29775243 | en_US |
dc.identifier.scopus | 2-s2.0-85053518883 | en_US |
dc.identifier.scopusquality | Q2 | en_US |
dc.identifier.startpage | 7479 | en_US |
dc.identifier.uri | https://doi.org/10.1002/jcb.27058 | |
dc.identifier.uri | https://hdl.handle.net/11616/98470 | |
dc.identifier.volume | 119 | en_US |
dc.identifier.wos | WOS:000445187800035 | en_US |
dc.identifier.wosquality | Q2 | en_US |
dc.indekslendigikaynak | Web of Science | en_US |
dc.indekslendigikaynak | Scopus | en_US |
dc.indekslendigikaynak | PubMed | en_US |
dc.language.iso | en | en_US |
dc.publisher | Wiley | en_US |
dc.relation.ispartof | Journal of Cellular Biochemistry | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | cardiotoxicity | en_US |
dc.subject | dexpanthenol | en_US |
dc.subject | heart | en_US |
dc.subject | isoproterenol | en_US |
dc.subject | oxidative stress | en_US |
dc.title | Protective and therapeutic effects of dexpanthenol on isoproterenol-induced cardiac damage in rats | en_US |
dc.type | Article | en_US |