Protective and therapeutic effects of dexpanthenol on isoproterenol-induced cardiac damage in rats

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dc.authoridTanriverdi, Lokman Hekim/0000-0003-4263-5234
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoridAcet, Ahmet/0000-0003-1131-1878
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridOzhan, Onural/0000-0001-9018-7849
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authorwosidTanriverdi, Lokman Hekim/M-5701-2015
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.authorwosidAcet, Ahmet/AAB-3273-2021
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.authorwosidOzhan, Onural/AAE-2356-2020
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.contributor.authorKalkan, Ferhat
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorDisli, Olcay M.
dc.contributor.authorTanriverdi, Lokman H.
dc.contributor.authorOzhan, Onural
dc.contributor.authorPolat, Alaaddin
dc.contributor.authorCetin, Asli
dc.date.accessioned2024-08-04T20:45:25Z
dc.date.available2024-08-04T20:45:25Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe purpose of the study was to explore the protective and therapeutic effects of dexpanthenol (DEX) on isoproterenol (ISO)-induced cardiac damage. Forty rats were distributed into four groups: group I (Control); group II (ISO); ISO (150mg/kg/day) was given to rats once a day for 2 consecutive days with an interval of 24h; group III (DEX+ISO): DEX (250mg/kg) was applied 30min before the first ISO administration and continued in the next two days after second ISO administration; group IV (ISO+DEX): After the ISO treatment at 1st and 2nd days, DEX was given at 3rd and 4th days. Rats were monitored for mean arterial blood pressure (BP), heart rate, oxygen saturation (%SO2), and electrocardiography (ECG). Heart tissue levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), reduced glutathione (GSH), total oxidant status (TOS); total antioxidant capacity (TAC), oxidative stress index (OSI), and caspase-3 were determined. BP and SO2 values indicated a significant decrease in the ISO group. Also, T wave negativity was observed in 6 of 10 rats, SOD, CAT, and GPX levels were significantly lower in ISO group than control group. ISO administration increased TOS and OSI levels, whereas DEX treatment significantly reduced these parameters. Also, ISO-induced morphological alterations such as disorganization of cardiomyocytes, loss of myofibrils and cytoplasmic vacuolization whereas these histological damages were significantly decreased in ISO+DEX and DEX+ISO groups when compared to the ISO group. This study implies the cardioprotective effects of DEX on ISO-induced cardiotoxicity.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey [2209/A-2012]en_US
dc.description.sponsorshipThe Scientific and Technological Research Council of Turkey, Grant number: 2209/A-2012en_US
dc.identifier.doi10.1002/jcb.27058
dc.identifier.endpage7489en_US
dc.identifier.issn0730-2312
dc.identifier.issn1097-4644
dc.identifier.issue9en_US
dc.identifier.pmid29775243en_US
dc.identifier.scopus2-s2.0-85053518883en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage7479en_US
dc.identifier.urihttps://doi.org/10.1002/jcb.27058
dc.identifier.urihttps://hdl.handle.net/11616/98470
dc.identifier.volume119en_US
dc.identifier.wosWOS:000445187800035en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Cellular Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcardiotoxicityen_US
dc.subjectdexpanthenolen_US
dc.subjecthearten_US
dc.subjectisoproterenolen_US
dc.subjectoxidative stressen_US
dc.titleProtective and therapeutic effects of dexpanthenol on isoproterenol-induced cardiac damage in ratsen_US
dc.typeArticleen_US

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