Plasma superoxide dismutase activity and malondialdehyde level correlate with the extent of acute appendicitis

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dc.authorwosidKARAMAN, Abdurrahman/G-7825-2016
dc.authorwosidUz, Efkan/B-2943-2016
dc.contributor.authorKoltuksuz, U
dc.contributor.authorUz, E
dc.contributor.authorÖzen, S
dc.contributor.authorAydinc, M
dc.contributor.authorKaraman, A
dc.contributor.authorAkyol, Ö
dc.date.accessioned2024-08-04T20:12:07Z
dc.date.available2024-08-04T20:12:07Z
dc.date.issued2000
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAlthough the mechanism of acute appendicitis (AA) is partly understood, the progression following the onset of inflammation has not yet been clarified. To determine oxidative activities in the plasma of patients with AA, superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels were measured in samples from 31 patients diagnosed as having AA and 10 otherwise healthy children with inguinal pathologies. The patients with AA were divided into three subgroups: acute focal (AFA) (n = 8), acute suppurative (ASA) (n = 9), and acute perforated appendicitis (APA) (n = 14), according to the intraoperative findings and histopathologic examination.. SOD and MDA were compared statistically between these subgroups and between them and the control group. Additionally, mean leukocyte counts of each group were determined and the differences between the groups were evaluated. Both SOD and MDA were significantly higher in the ASA and APA groups compared to controls and AFA group. The mean leukocyte numbers of the ASA and APA groups were significantly higher compared to the AFA group. Based to these results, it may be speculated that oxygen free radicals (OFR) may play an important role in the extent of AA. To prevent the hazardous effects of OFR, the organism may increase SOD and other antioxidant enzyme levels and/or activities.en_US
dc.identifier.doi10.1007/s003830000424
dc.identifier.endpage561en_US
dc.identifier.issn0179-0358
dc.identifier.issue8en_US
dc.identifier.pmid11149393en_US
dc.identifier.scopus2-s2.0-0033671828en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage559en_US
dc.identifier.urihttps://doi.org/10.1007/s003830000424
dc.identifier.urihttps://hdl.handle.net/11616/93216
dc.identifier.volume16en_US
dc.identifier.wosWOS:000165611700005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer-Verlagen_US
dc.relation.ispartofPediatric Surgery Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectacute appendicitisen_US
dc.subjectoxygen radicalsen_US
dc.subjectsuperoxide dismutaseen_US
dc.subjectmalondialdehydeen_US
dc.titlePlasma superoxide dismutase activity and malondialdehyde level correlate with the extent of acute appendicitisen_US
dc.typeArticleen_US

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