Decreased platelet activation and endothelial dysfunction after percutaneous mitral balloon valvuloplasty

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dc.authorwosidIleri, Mehmet/A-6525-2018
dc.contributor.authorYetkin, E
dc.contributor.authorErbay, AR
dc.contributor.authorTurhan, H
dc.contributor.authorIleri, M
dc.contributor.authorAyaz, S
dc.contributor.authorAtak, R
dc.contributor.authorSenen, K
dc.date.accessioned2024-08-04T20:13:49Z
dc.date.available2024-08-04T20:13:49Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: This study was conducted to assess the changes in platelet activation and endothelial dysfunction in patients with mitral stenosis (MS) and sinus rhythm (SR) following percutaneous mitral balloon valvuloplasty (PMBV). Background: Systemic thromboembolism is a serious complication in patients with valvular heart disease, and its incidence is highest in those with mitral stenosis. A hypercoagulable state has also been reported in patients with mitral stenosis and sinus rhythm. A recent study has shown that patients with previous PMBV had a lower incidence of thromboembolism. Methods and results: The study was conducted in 21 patients (two men, 19 women, mean age=34+/-6 years) with mitral stenosis and sinus rhythm (SR) who underwent percutaneous mitral balloon valvuloplasty and 17 healthy control subjects (two men, 15 women, mean age=33+/-6 years). Biochemical markers of platelet activity (beta thromboglobulin, BTG, and soluble P-selectin, sPsel) and endothelial dysfunction (von Willebrand Factor, vWF) were measured in both control subjects' and patients' serum samples taken immediately before PMBV and 24 h after PMBV procedure. All patients underwent successful PMBV Significant improvement of mitral valve area, pulmonary artery pressure, mean mitral gradients, and left atrial diameter were achieved in all patients after PMBV Compared with control subjects, patients with MS had higher plasma levels of BTG (66+/-26 ng/ml vs. 14+/-6 ng/ml, P<0.001), vWF (177+/-67 units/dl vs. 99+/-37 units/dl, P<0.0001), sPsel (226+/-74 ng/ml vs. 155+/-66 ng/ml, P<0.001). There was a significant reduction of plasma levels of BTG (66 +/- 26 ng/ml vs. 48 +/- 20 ng/ml, P=0.002), vWF (177 +/- 67 units/dl vs. 134 +/- 60 units/dl, P=0.001) and P-selectin (226 +/- 74 ng/ml vs. 173 +/- 71 ng/ml, P=0.008,) 24 h after PMBV Conclusion: We have shown that patients with severe MS and SR have increased platelet activation and endothelial dysfunction compared with control subjects and PMBV results in decreased platelet activity and improvement of endothelial injury. (c) 2003 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/S0167-5273(03)00027-5
dc.identifier.endpage225en_US
dc.identifier.issn0167-5273
dc.identifier.issn1874-1754
dc.identifier.issue2-3en_US
dc.identifier.pmid14559134en_US
dc.identifier.scopus2-s2.0-1642326027en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage221en_US
dc.identifier.urihttps://doi.org/10.1016/S0167-5273(03)00027-5
dc.identifier.urihttps://hdl.handle.net/11616/93866
dc.identifier.volume91en_US
dc.identifier.wosWOS:000186114800014en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofInternational Journal of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectendothelial dysfunctionen_US
dc.subjectplatelet activationen_US
dc.subjectmitral stenosisen_US
dc.subjectmitral balloon valvuloplastyen_US
dc.titleDecreased platelet activation and endothelial dysfunction after percutaneous mitral balloon valvuloplastyen_US
dc.typeArticleen_US

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