A light microscopic investigation of the renoprotective effects of ?-lipoic acid and ?-tocopherol in an experimental diabetic rat model

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dc.authoridBAHAR, LEYLA/0000-0002-6910-6167
dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridGül, Semir/0000-0002-4668-9603
dc.authoridKayhan Kustepe, Elif/0000-0002-0030-5862
dc.authorwosidBAHAR, LEYLA/Y-3908-2019
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidGül, Semir/ABI-8244-2020
dc.contributor.authorKustepe, Elif Kayhan
dc.contributor.authorBahar, Leyla
dc.contributor.authorZayman, Emrah
dc.contributor.authorSucu, Nehir
dc.contributor.authorGul, Semir
dc.contributor.authorGul, Mehmet
dc.date.accessioned2024-08-04T20:47:16Z
dc.date.available2024-08-04T20:47:16Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe investigated the effects of alpha-lipoic acid (AL) and alpha-tocopherol (AT) on renal histopathology in a streptozotocin (STZ) induced diabetic rat model. Adult male rats were divided into six groups: group 1, saline only; group 2, AL only; group 3, AT only; group 4, STZ only; group 5, STZ + AL; group 6 STZ + AT. Experimental diabetes was induced by STZ. AL and AT were administered for 15 days. Kidney sections were examined using a light microscope after hematoxylin and eosin (H & E), periodic acid-Schiff (PAS) and caspase-3 staining. Histological damage to glomeruli, tubule epithelial cells and basement membrane was observed in group 4. Administration of AT and AL reduced renal injury in the diabetic rats. Group 5 exhibited a greater curative effect on diabetic rats than group 6. AT and AL may be useful for preventing diabetic renal damage.en_US
dc.description.sponsorshipResearch Support Unit of Mersin University [2017-1-AP2-2208]en_US
dc.description.sponsorshipThis study was supported by the Research Support Unit of Mersin University under project no. 2017-1-AP2-2208.en_US
dc.identifier.doi10.1080/10520295.2019.1695942
dc.identifier.endpage316en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue4en_US
dc.identifier.pmid32013590en_US
dc.identifier.scopus2-s2.0-85084380177en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage305en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2019.1695942
dc.identifier.urihttps://hdl.handle.net/11616/99274
dc.identifier.volume95en_US
dc.identifier.wosWOS:000512571700001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectalpha-lipoic aciden_US
dc.subjectalpha-tocopherolen_US
dc.subjectdiabetesen_US
dc.subjectkidneyen_US
dc.subjectraten_US
dc.subjectstreptozotocinen_US
dc.titleA light microscopic investigation of the renoprotective effects of ?-lipoic acid and ?-tocopherol in an experimental diabetic rat modelen_US
dc.typeArticleen_US

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