Effects of propofol and dexmedetomidine on motor coordination and analgesia: A comparative analysis

Basit Öğe Kaydı
dc.authoridUçar, Muharrem/0000-0002-1232-9829
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridYücel, Aytaç/0000-0003-0270-8339
dc.authoridDurmus, Mahmut/0000-0001-9594-9064
dc.authoridaydogan, mustafa said/0000-0002-7106-1156
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468;
dc.authorwosidUçar, Muharrem/ABH-7761-2020
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidErdogan, Mehmet Ali/ABI-7224-2020
dc.authorwosidYücel, Aytaç/ABI-6137-2020
dc.authorwosidDurmus, Mahmut/ABH-3006-2020
dc.authorwosidaydogan, mustafa said/AAA-2828-2021
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.contributor.authorYucel, Aytac
dc.contributor.authorAydogan, M. Said
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorErdogan, M. Ali
dc.contributor.authorKurt, Ahmet
dc.contributor.authorUcar, Muharrem
dc.contributor.authorDurmus, Mahmut
dc.date.accessioned2024-08-04T20:36:10Z
dc.date.available2024-08-04T20:36:10Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: The objective of this study was to compare the effects of two drugs on motor performance and analgesic efficacy in a rat model. Material and methods: Rats were randomly divided into four groups as follows: propofol (600 mu g/kg/min), dexmedetomidine (1 mu g/kg/min), morphine (83 mu g/kg/min) and control. The rats were placed on a rotating rod and tested at the slowest speed (5 rpm) and then at increasing increments from 5, 10, 15, 20, 25, 30, 35 to 40 rpm. The speed was set up again from 1 to 79 rpm within 4 and 10 min for the accelerod test, respectively. Pain reflexes in response to a thermal stimulus were measured at 0, 10, 20 and 60 min after the drug injection using the hot-plate test. Results: Dexmedetomidine injected rats showed an increased length of time compared to the propofol group at 20 rpm, 25 rpm, 35 rpm and 40 rpm speeds during the rotarod test. The latency times for the hot-plate test increased significantly for the propofol, at 0, 10 and 20 min compared to the control. At 10 min the latency times of the propofol group were longer than the dexmedetomidine group. Conclusions: For long-term analgesic benefit, propofol treatment seems to be better than the dexmedetomidine group. Dexmedetomidine may be preferable in day-case surgery and sedation applications in intensive care units as it provided a faster onset of recovery of motor coordination performance.en_US
dc.identifier.doi10.5414/CP201696
dc.identifier.endpage682en_US
dc.identifier.issn0946-1965
dc.identifier.issue9en_US
dc.identifier.pmid22784610en_US
dc.identifier.scopus2-s2.0-84866511796en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage678en_US
dc.identifier.urihttps://doi.org/10.5414/CP201696
dc.identifier.urihttps://hdl.handle.net/11616/95806
dc.identifier.volume50en_US
dc.identifier.wosWOS:000309634500009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherDustri-Verlag Dr Karl Feistleen_US
dc.relation.ispartofInternational Journal of Clinical Pharmacology and Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmotor impairmenten_US
dc.subjectrotaroden_US
dc.subjectacceleroden_US
dc.subjecthot-plateen_US
dc.subjectdexmedetomidineen_US
dc.subjectpropofolen_US
dc.titleEffects of propofol and dexmedetomidine on motor coordination and analgesia: A comparative analysisen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu