The effect of verapamil in the prevention of radiation-induced cataract

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dc.contributor.authorCengiz, M
dc.contributor.authorGürkaynak, M
dc.contributor.authorAtahan, IL
dc.contributor.authorKilic, K
dc.contributor.authorTotan, Y
dc.date.accessioned2024-08-04T20:13:32Z
dc.date.available2024-08-04T20:13:32Z
dc.date.issued1999
dc.departmentİnönü Üniversitesien_US
dc.description9th European Cancer Conference -- SEP 14-18, 1997 -- HAMBURG, GERMANYen_US
dc.description.abstractPurpose: Cataract is an unavoidable complication when radiation therapy includes the lens, even in small doses. Alterations in the ion content of the lens were considered to play an essential role in cataract formation. In this experimental study, the effect of verapamil on ion concentrations within the irradiated lenses was investigated in rats. Methods and Materials: Forty female Wistar albino rats, each weighing 180-250 g, were divided into three groups: (a) radiation treated (n = 10); (b) no treatment (n = 10); (c) or a combination of radiation and verapamil (n = 20), Both the radiation group and verapamil-treated group received 5 Gy radiation to the cranium in a single fraction, including the eyes, within the irradiation volume. All animals were sacrificed by bleeding, 7.5 weeks posttreatment. Calcium, sodium, and potassium levels were measured in blood and in lens homogenates, However, for technical reasons, magnesium levels could only be studied in lens homogenates. Results: Potassium and sodium concentrations in lens homogenates did not differ in the control and radiation groups, but both were significantly lower in the verapamil-treated group (p = 0.001, p = 0.009, respectively). Calcium levels were higher in the radiation group and lower in the verapamil-treated group compared to the controls (p < 0.0001); magnesium levels did not differ (p = 0.37). Conclusion: Verapamil effectively decreased the lens calcium concentration, which is accepted as the key element in radiation cataractogenesis, It is therefore concluded that verapamil may reduce the risk of radiation-induced cataract formation. (C) 1999 Elsevier Science Inc.en_US
dc.identifier.doi10.1016/S0360-3016(98)00458-1
dc.identifier.endpage626en_US
dc.identifier.issn0360-3016
dc.identifier.issue3en_US
dc.identifier.pmid10078648en_US
dc.identifier.scopus2-s2.0-0344699391en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage623en_US
dc.identifier.urihttps://doi.org/10.1016/S0360-3016(98)00458-1
dc.identifier.urihttps://hdl.handle.net/11616/93683
dc.identifier.volume43en_US
dc.identifier.wosWOS:000078911600025en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofInternational Journal of Radiation Oncology Biology Physicsen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectradiation-induced cataracten_US
dc.subjectverapamilen_US
dc.subjectcalcium-channel blockeren_US
dc.subjectcalciumen_US
dc.titleThe effect of verapamil in the prevention of radiation-induced cataracten_US
dc.typeConference Objecten_US

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