Blood pressure is normal, but is the heart?

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dc.authoridYologlu, Saim/0000-0002-9619-3462
dc.authoridçelik, serkan f/0000-0003-1595-802X
dc.authoridKARAKURT, CEMŞIT/0000-0002-9246-8107
dc.authorwosidYologlu, Saim/ABI-8014-2020
dc.authorwosidçelik, serkan f/JWP-2387-2024
dc.authorwosidTabel, Yilmaz/AAF-9801-2020
dc.authorwosidKARAKURT, CEMŞIT/ABE-2330-2020
dc.contributor.authorCelik, Serkan Fazli
dc.contributor.authorKarakurt, Cemsit
dc.contributor.authorTabel, Yilmaz
dc.contributor.authorElmas, Taner
dc.contributor.authorYologlu, Saim
dc.date.accessioned2024-08-04T20:44:30Z
dc.date.available2024-08-04T20:44:30Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThere is no detailed strain analysis of cardiac functions in treated hypertensive pediatric patients. The aim of this study was to evaluate the cardio-protective effects of different drug classes in treated pediatric hypertensive patients. Sixty non-obese-treated hypertensive patients with preserved left ventricular (LV) systolic function and 45 age-, sex-, and body mass index-matched healthy subjects underwent clinical evaluation, including 24-h ambulatory blood pressure monitoring, standard echocardiographic examination, tissue Doppler imaging, and two-dimensional Speckle Tracking Echocardiography. The patients were divided into two subgroups based on the effects of the drugs on the Renin Angiotensin Aldosterone System. The subgroup hypertension (HT) 1 received angiotensin-converting enzyme inhibitor or angiotensin receptor blocker, and HT 2 subgroup received calcium channel blocker, beta-blocker, or diuretics. There was no difference between the two groups and subgroups with respect to clinical, demographic, ABPM, ventricular volumes, ejection fraction, and tissue Doppler imaging (TDI) parameters. For patients and controls, respectively, global longitudinal strain was - 18.70 +/- 3.41 versus - 21.01 +/- 3.82 (P < 0.001), and global radial strain was 40.6 +/- 9.8 versus 54.8 +/- 12.8 (P = 0.004). Peak LV twist and peak LV torsion were not significantly different. The patient subgroup analyses with each other revealed no difference in systolic and diastolic myocardial deformation properties. Strain parameters were reduced in all treated hypertensive children compared to normotensive children, and the various cardiac mechanic parameters were similarly abnormal no matter what type of antihypertensive agent was used.en_US
dc.identifier.doi10.1007/s00467-018-3968-5
dc.identifier.endpage1591en_US
dc.identifier.issn0931-041X
dc.identifier.issn1432-198X
dc.identifier.issue9en_US
dc.identifier.pmid29766272en_US
dc.identifier.scopus2-s2.0-85046907409en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1585en_US
dc.identifier.urihttps://doi.org/10.1007/s00467-018-3968-5
dc.identifier.urihttps://hdl.handle.net/11616/98287
dc.identifier.volume33en_US
dc.identifier.wosWOS:000440081700017en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChilden_US
dc.subjectHypertensionen_US
dc.subjectAntihypertensive drugsen_US
dc.subjectStrainen_US
dc.subjectSystolic functionen_US
dc.titleBlood pressure is normal, but is the heart?en_US
dc.typeArticleen_US

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