Evaluation of vaspin and irisin hormones levels in diabetic rats and relationship with diet

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dc.authoridÇELIKKOL, ALIYE/0000-0002-3799-4470
dc.authoridBozkır, Çiğdem/0000-0002-1103-6290
dc.authoridTuggum, Sergen/0000-0002-0519-7039
dc.authorwosidÇELIKKOL, ALIYE/ABE-2695-2020
dc.authorwosidaslan, serkan/O-9637-2018
dc.authorwosidYilmaz, Ahsen/ABB-1083-2021
dc.authorwosidBozkır, Çiğdem/ABA-6429-2020
dc.contributor.authorTuggum, Sergen
dc.contributor.authorBozkir, Cigdem
dc.contributor.authorAslan, Serkan
dc.contributor.authorYilmaz, Ahsen
dc.contributor.authorCelikkol, Aliye
dc.date.accessioned2024-08-04T20:53:05Z
dc.date.available2024-08-04T20:53:05Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBACKGROUND: Type-2 diabetes with an increasing prevalence is a public health problem. Irisin and vaspin, which are secreted a majority from adipose tissue, are discovered hormones recently, and their effects on diabetes are studied. OBJECTIVE: This study aims to the effects of diet on these hormones levels in diabetic rats. METHODS: In this study, ten-week-old 18 Wistar-Albino rats were divided into three groups randomly. The diabetic group (n = 6) was fed a high-fat diet (HFD). Other rats were divided into two control groups, one of them (n = 6) was fed a control diet (CD), and the other group (n = 6) was fed HFD. The feeding time for all groups was 4 weeks. Streptozotocin (STZ) was used for diabetes induction in rats. RESULTS: At the end of the four weeks, the body weight of the diabetic group decreased significantly. In the diabetic group compared to the control groups, it was observed that besides high fasting blood glucose (FBG), triglyceride, total cholesterol levels, and insulin resistance (HOMA-IR) scores. Vaspin levels were significantly higher in diabetic rats, while irisin levels were similar between groups. Besides, vaspin level correlation with biochemical parameters such as glucose, triglycerides, total cholesterol, and HOMA-IR score was significant. CONCLUSION: In conclusion, this study showed that besides the evidence that vaspine is a hormone associated with diabetes, diet composition could give an opinion about the type-2 diabetes process by looking at hormone levels.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Tekirda.g Namik Kemal University [NKUBAP.23, YL.20.243]en_US
dc.description.sponsorshipThe authors disclosed receipt of the following financial support for the research and/or publication of this article: This study was funded by the Scientific Research Projects Coordination Unit of Tekirda.g Namik Kemal University (NKUBAP.23.YL.20.243).en_US
dc.identifier.doi10.3233/MNM-211586
dc.identifier.endpage428en_US
dc.identifier.issn1973-798X
dc.identifier.issn1973-7998
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85140847409en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage419en_US
dc.identifier.urihttps://doi.org/10.3233/MNM-211586
dc.identifier.urihttps://hdl.handle.net/11616/100964
dc.identifier.volume15en_US
dc.identifier.wosWOS:000856617700011en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherIos Pressen_US
dc.relation.ispartofMediterranean Journal of Nutrition and Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetesen_US
dc.subjectirisinen_US
dc.subjectvaspinen_US
dc.subjectnutritionen_US
dc.subjecthigh fat dieten_US
dc.titleEvaluation of vaspin and irisin hormones levels in diabetic rats and relationship with dieten_US
dc.typeArticleen_US

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