Investigation of anticancer effects of Meteorin like protein on different human cancer cell lines

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dc.contributor.authorSekerci, Guldeniz
dc.contributor.authorBeytur, Leyla
dc.contributor.authorYuksel, Furkan
dc.contributor.authorTekin, Suat
dc.date.accessioned2024-08-04T19:42:45Z
dc.date.available2024-08-04T19:42:45Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: Cancer is one of the biggest health problems threatening humanity, and the fight against cancer continues with different methods worldwide. Despite advances in cancer prevention and treatment, the low success rate and tumor recurrence make the discovery of new alternative agents important. Adipokines are among those known to be associated with cancer. The relationship of the peptide-structured Meteorin like protein (Metrnl), a member of the adipokine family, discovered in 2012, with cancer remains a mystery. This study was conducted to examine the cytotoxic effects of Metrnl on human ovarian, prostate, colon and breast cancer cell lines. Materials and Methods: In the study, ovarian (A2780), human prostate (LNCaP), colon (Caco-2) and breast cancer (MCF-7) cell lines were used. After the cells were incubated with 1, 5, 10, 50, 100 and 200 ng/mL Metrnl for 24 h, the cytotoxicity level was determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5diphenyltetrazolium bromide (MTT) assay method. determined. Comparisons between groups were made with the Kruskal Wallis H-Test. Results: Concentrations of Metrnl significantly reduced cell viability in A2780, LNCaP, Caco-2 and MCF-7 cell lines (p<0.05). Conclusion: These results show that Metrnl may have anticarcinogenic activity on A2780, LNCaP, Caco-2 and MCF-7 cells, but further studies are needed on this subject.en_US
dc.identifier.doi10.5455/annalsmedres.2024.06.117
dc.identifier.endpage564en_US
dc.identifier.issn2636-7688
dc.identifier.issue7en_US
dc.identifier.startpage560en_US
dc.identifier.trdizinid1251741en_US
dc.identifier.urihttps://doi.org/10.5455/annalsmedres.2024.06.117
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1251741
dc.identifier.urihttps://hdl.handle.net/11616/88654
dc.identifier.volume31en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofAnnals of Medical Researchen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleInvestigation of anticancer effects of Meteorin like protein on different human cancer cell linesen_US
dc.typeArticleen_US

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