The effect of dexmedetomidine against oxidative and tubular damage induced by renal ischemia reperfusion in rats

Basit Öğe Kaydı
dc.authoridTekin, Suat/0000-0002-2757-1802
dc.authoridTanbek, Kevser/0000-0003-2099-2273
dc.authoridCakir, Murat/0000-0002-2066-829X
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridTANBEK, Kevser/0000-0003-2099-2273
dc.authoridTaslidere, Elif/0000-0003-1723-2556
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authorwosidTekin, Suat/KEI-2266-2024
dc.authorwosidTekin, Suat/IZD-9868-2023
dc.authorwosidTekin, Suat/AAG-1440-2021
dc.authorwosidTanbek, Kevser/ABI-1174-2020
dc.authorwosidCakir, Murat/I-8643-2019
dc.authorwosidPolat, Alaadin/Q-4052-2018
dc.authorwosidTANBEK, Kevser/ITR-9264-2023
dc.contributor.authorCakir, Murat
dc.contributor.authorPolat, Alaadin
dc.contributor.authorTekin, Suat
dc.contributor.authorVardi, Nigar
dc.contributor.authorTaslidere, Elif
dc.contributor.authorDuran, Zeynep Rumeysa
dc.contributor.authorTanbek, Kevser
dc.date.accessioned2024-08-04T20:40:17Z
dc.date.available2024-08-04T20:40:17Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractDexmedetomidine (dex) is a potent, highly selective and specific alpha 2-adrenoreceptor agonist. This experimental study was designed to investigate protective and therapeutic effect of two different doses of dex, on kidney damage induced by ischemia-reperfusion (I/R) in rats. Male Sprague - Dawley rats were divided into four groups, each including 10 animals: control group, ischemia-reperfusion (I/R) group; treated groups with 10 mu g/kg of dex and 100 mu g/kg of dex. After removing right kidney of the rats, the left kidney has performed ischemia during 40 min and reperfusion in the following 3 h. The histopathological findings, and also tissue superoxide dismutase (SOD) and catalase (CAT) enzyme activity, malondialdehyde (MDA), glutathione (GSH), serum blood urea nitrogen (BUN), creatinine (Cre) and tumor necrosis factor-alpha (TNF-alpha) levels were determined. In the I/R group, compared to the control group, levels of BUN, Cre and kidney tissue MDA have increased significantly, SOD, CAT enzyme activity and glutathione levels have decreased significantly. In the dex10 group, compared to the I/R group, levels of Cre and TNF-alpha have decreased significantly, while the SOD activity has increased significantly. In the dex100 group, compared to the I/R group, levels of BUN, Cre have decreased significantly, while the SOD activity has increased significantly. In the I/R group, there was also extensive tubular necrosis, glomerular damage in the histological evaluation. Dex ameliorated these histological damages in different amounts in two treatment groups. In this study, the protective effects of dex against renal I/R injury have been evaluated by two different amount of doses.en_US
dc.description.sponsorshipInonu University Department of Scientific Research Projects [2011/59]en_US
dc.description.sponsorshipThis study was supported by Inonu University Department of Scientific Research Projects (Project no: 2011/59). No competing interests declared.en_US
dc.identifier.doi10.3109/0886022X.2015.1011550
dc.identifier.endpage708en_US
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue4en_US
dc.identifier.pmid25687385en_US
dc.identifier.scopus2-s2.0-84930326199en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage704en_US
dc.identifier.urihttps://doi.org/10.3109/0886022X.2015.1011550
dc.identifier.urihttps://hdl.handle.net/11616/96805
dc.identifier.volume37en_US
dc.identifier.wosWOS:000355941500026en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofRenal Failureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDexmedetomidineen_US
dc.subjectischemia-reperfusionen_US
dc.subjectoxidative stressen_US
dc.subjectraten_US
dc.subjectrenalen_US
dc.titleThe effect of dexmedetomidine against oxidative and tubular damage induced by renal ischemia reperfusion in ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu