Effect of HBV-HDV co-infection on HBV-HCC co-recurrence in patients undergoing living donor liver transplantation

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dc.authoridSAHIN, TEVFIK TOLGA/0000-0002-9132-6115
dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridince, volkan/0000-0002-0714-490X
dc.authoridAkbulut, Sami/0000-0002-6864-7711
dc.authoridBASKIRAN, ADIL/0000-0002-7536-1631
dc.authoridKARAKAS, SERDAR/0000-0001-8314-7806
dc.authoridKoc, Cemalettin/0000-0002-5676-6772
dc.authorwosidSAHIN, TEVFIK TOLGA/AAA-9648-2021
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.authorwosidince, volkan/M-7325-2017
dc.authorwosidAkbulut, Sami/L-9568-2014
dc.authorwosidBASKIRAN, ADIL/ABI-2356-2020
dc.authorwosidKARAKAS, SERDAR/AAB-3219-2021
dc.authorwosidKoc, Cemalettin/B-6430-2018
dc.contributor.authorBaskiran, Adil
dc.contributor.authorAkbulut, Sami
dc.contributor.authorSahin, Tevfik Tolga
dc.contributor.authorKoc, Cemalettin
dc.contributor.authorKarakas, Serdar
dc.contributor.authorInce, Volkan
dc.contributor.authorYurdaydin, Cihan
dc.date.accessioned2024-08-04T20:48:54Z
dc.date.available2024-08-04T20:48:54Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose To evaluate the effect of hepatitis D virus (HDV) on hepatitis B virus-hepatocellular carcinoma (HBV-HCC) co-recurrence in patients undergoing living donor liver transplantation (LDLT) for HBV alone or HBV-HDV coinfection. Methods Between 2002 and 2019, 254 HBV-HCC patients underwent LDLT. The patients were divided into two groups after the application of the exclusion criteria: HBV-HCC (Group B;n = 163) and HBV-HDV-HCC (Group D;n = 31). First, the B and D groups were compared in terms of demographic and clinical parameters. Second, patients with (n = 16) and without (n = 178) post-transplant HBV-HCC co-recurrences were grouped and compared in terms of the same parameters. Results Although the risk of HBV-HCC co-recurrence in group D was 4.99-fold higher than in group B, the risk of HBV recurrence alone in group D was 12.5-fold lower than in group B. The AFP (OR = 4.4), Milan criteria (beyond; OR = 18.8), and HDV (OR = 8.1) were identified as the independent risk factors affecting post-transplant HBV-HCC co-recurrence. The Milan criteria (OR = 2.1) and HBV-HCC co-recurrence (OR = 10.9) were identified as the risk factors affecting post-transplant mortality. HBV-HCC co-recurrence developed in 26.5% of patients in Group B and 100% in Group D (OR = 40;p = 0.001). HCC recurrence alone developed in 10% of patients without HBV recurrence in group B and 0% of patients without HBV recurrence in group D (OR = 5.7). Conclusion This study showed that the risk of HBV recurrence alone was reduced by 12.5-fold in the presence of HDV; however, the HCC recurrence occurred in all patients with HDV when HBV recurrence developed.en_US
dc.identifier.doi10.1007/s12072-020-10085-3
dc.identifier.endpage880en_US
dc.identifier.issn1936-0533
dc.identifier.issn1936-0541
dc.identifier.issue5en_US
dc.identifier.pmid32895876en_US
dc.identifier.scopus2-s2.0-85090305845en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage869en_US
dc.identifier.urihttps://doi.org/10.1007/s12072-020-10085-3
dc.identifier.urihttps://hdl.handle.net/11616/99522
dc.identifier.volume14en_US
dc.identifier.wosWOS:000566873000001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofHepatology Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLiver transplantationen_US
dc.subjectHCCen_US
dc.subjectHBVen_US
dc.subjectHDVen_US
dc.subjectHBV recurrence aloneen_US
dc.subjectHCC recurrence aloneen_US
dc.subjectHBV-HCC co-recurrenceen_US
dc.titleEffect of HBV-HDV co-infection on HBV-HCC co-recurrence in patients undergoing living donor liver transplantationen_US
dc.typeArticleen_US

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