Protective effect of melatonin on random pattern skin flap necrosis in pinealectomized rat

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dc.authoridbay karabulut, aysun/0000-0002-7873-2805
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridAcet, Ahmet/0000-0003-1131-1878
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authorwosidbay karabulut, aysun/HJP-0995-2023
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidAcet, Ahmet/AAB-3273-2021
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.contributor.authorGurlek, A
dc.contributor.authorAydogan, H
dc.contributor.authorParlakpinar, H
dc.contributor.authorBay-Karabulut, A
dc.contributor.authorCelik, M
dc.contributor.authorSezgin, N
dc.contributor.authorAcet, A
dc.date.accessioned2024-08-04T20:13:49Z
dc.date.available2024-08-04T20:13:49Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractRandom pattern skin flaps are still widely used in plastic surgery. However, necrosis in the distal portion resulting from ischemia is a serious problem, increasing the cost of treatment and hospitalization. Free oxygen radicals and increased neutrophil accumulation play an important role in tissue injury and may lead to partial or complete flap necrosis. To enhance skin flap viability, a variety of pharmacological agents have been intensively investigated. The aim of this study is to test the effects of melatonin, the chief secretory product of the pineal gland and a highly effective antioxidant, on random pattern skin flap survival in rats. Herein, to investigate the physiological and pharmacological role of melatonin on dorsal skin flap survival. Pharmacological (0.4, 4 and 40 mg/kg) levels of melatonin were given intraperitoneally (i.p.). For this, pinealectomized (Px) and sham operated (non-Px) rats were used. The effects of melatonin on levels of malondialdehyde (MDA), nitric oxide (NO), glutathione (GSH) and the activities of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) were measured in the skin flap. The ratio of skin flap necrosis was compared among the experimental groups by using planimetry. MDA and NO levels were found to be higher in Px than non-Px rats; while GSH levels and GSH-Px, and SOD activities were reduced. Melatonin administration to Px rats reduced MDA and NO levels and increased GSH, GSH-Px, SOD levels. Melatonin also reduced the ratio of flap necrosis determined by using planimetry and supported through the photography. In conclusion, these results show that both physiological and pharmacological concentrations of melatonin improve skin flap viability.en_US
dc.identifier.doi10.1046/j.1600-079X.2003.00099.x
dc.identifier.endpage63en_US
dc.identifier.issn0742-3098
dc.identifier.issue1en_US
dc.identifier.pmid14675131en_US
dc.identifier.scopus2-s2.0-1642440095en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage58en_US
dc.identifier.urihttps://doi.org/10.1046/j.1600-079X.2003.00099.x
dc.identifier.urihttps://hdl.handle.net/11616/93868
dc.identifier.volume36en_US
dc.identifier.wosWOS:000187275900008en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBlackwell Munksgaarden_US
dc.relation.ispartofJournal of Pineal Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectmalondialdehydeen_US
dc.subjectmelatoninen_US
dc.subjectpinealectomyen_US
dc.subjectrandom pattern skin flapen_US
dc.subjectraten_US
dc.titleProtective effect of melatonin on random pattern skin flap necrosis in pinealectomized raten_US
dc.typeArticleen_US

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