In vitro and histological investigation of antitumor effect of some triazole compounds in colon cancer cell line

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dc.authoridTekin, Suat/0000-0002-2757-1802
dc.authoridKaratepe, Mustafa/0000-0001-6358-5913
dc.authoridPARLAK, AKIF EVREN/0000-0002-2579-9985
dc.authoridCeribasi, Ali Osman/0000-0002-6096-4042
dc.authoridKoparir, Pelin/0000-0002-3981-9748
dc.authorwosidÇERİBAŞI, Osman O/W-5932-2018
dc.authorwosidTekin, Suat/KEI-2266-2024
dc.authorwosidKaratepe, Mustafa/HII-5655-2022
dc.authorwosidTekin, Suat/AAG-1440-2021
dc.authorwosidTekin, Suat/IZD-9868-2023
dc.authorwosidPARLAK, AKIF EVREN/GNO-9528-2022
dc.authorwosidCeribasi, Ali Osman/V-8209-2018
dc.contributor.authorParlak, Akif Evren
dc.contributor.authorTekin, Suat
dc.contributor.authorKaratepe, Arzu
dc.contributor.authorKoparir, Pelin
dc.contributor.authorTelceken, Hafize
dc.contributor.authorCeribasi, Ali Osman
dc.contributor.authorKaratepe, Mustafa
dc.date.accessioned2024-08-04T20:45:43Z
dc.date.available2024-08-04T20:45:43Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstract1,2,4-Triazoles are used as antifungal, antibacterial, antimicrobial, and antioxidant against some oxidative radical species. Recently, many 1,2,4-triazoles continue to be synthesized. In this study, the effect of the 1,2,4-triazole derivatives on human colon cancer (HT29) was investigated in vitro and in vivo in rats. MTT test was applied to in in vitro experiments. For in vivo study, rats were divided into seven groups as follows: Control group (negative control), azoxymethane (AOM), AOM+cisplatin 15, AOM+L1, AOM+L2, AOM+L3, and AOM+L4. To create colon cancer, the AOM injection was injected subcutaneously at a dose of 15mg/kg, three times (once weekly). The in vivo studies were completed at 28 weeks. It was found that the 1,2,4-triazole derivatives reduced the cell viability (P<0.05). In all animals in the experimental groups, mild dysplasia was detected in 100% of the colon mucosal epithelium. Severe dysplasia and adenocarcinoma were observed in L1 groups. As a result, this study determined that the 1,2,4-triazole derivatives exhibit antitumor activity.en_US
dc.description.sponsorshipManagement Unit of Scientific Research Projects of Firat University (FUBAP) [F.F.15.06]; Management Unit of Scientific Research Projects of Firat Universityen_US
dc.description.sponsorshipThe financial support of The Management Unit of Scientific Research Projects of Firat University (FUBAP), Grant/Award Number: (Project Number F.F.15.06); The Management Unit of Scientific Research Projects of Firat Universityen_US
dc.identifier.doi10.1002/jcb.28460
dc.identifier.endpage11819en_US
dc.identifier.issn0730-2312
dc.identifier.issn1097-4644
dc.identifier.issue7en_US
dc.identifier.pmid30770576en_US
dc.identifier.scopus2-s2.0-85061631271en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage11809en_US
dc.identifier.urihttps://doi.org/10.1002/jcb.28460
dc.identifier.urihttps://hdl.handle.net/11616/98657
dc.identifier.volume120en_US
dc.identifier.wosWOS:000471300600092en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Cellular Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectazoxymethaneen_US
dc.subjectcolon canceren_US
dc.subjectHT29en_US
dc.subject1en_US
dc.subject2en_US
dc.subject4-triazoleen_US
dc.titleIn vitro and histological investigation of antitumor effect of some triazole compounds in colon cancer cell lineen_US
dc.typeArticleen_US

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