The Clinical Characteristics and Outcomes of COVID-19 Patients with Pre-Existing Thyroid Dysfunction: A Nationwide Study

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dc.authoridSonmez, Alper/0000-0002-9309-7715
dc.authoridsahin, mustafa/0000-0002-4718-0083
dc.authoridSatman, Ilhan/0000-0001-8613-1797
dc.authoridDagdelen, Selcuk/0000-0002-0513-1750
dc.authoridDemirci, Ibrahim/0000-0003-0498-3115;
dc.authorwosidSonmez, Alper/H-8588-2019
dc.authorwosidsahin, mustafa/AAH-3394-2019
dc.authorwosidSatman, Ilhan/AAS-7044-2020
dc.authorwosidDagdelen, Selcuk/A-9432-2017
dc.authorwosidUstun, Yaprak/KFQ-9767-2024
dc.authorwosidDemirci, Ibrahim/AAR-3277-2020
dc.authorwosidCelik, Osman/KLZ-6766-2024
dc.contributor.authorSahin, Mustafa
dc.contributor.authorDemirci, Ibrahim
dc.contributor.authorHaymana, Cem
dc.contributor.authorTasci, Ilker
dc.contributor.authorEmral, Rifat
dc.contributor.authorCakal, Erman
dc.contributor.authorUnluturk, Ugur
dc.date.accessioned2024-08-04T20:53:12Z
dc.date.available2024-08-04T20:53:12Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractTo which extent the pre-existing hypothyroidism or hyperthyroidism has an impact on coronavirus infection 2019 (COVID-19) outcomes remains unclear. The objective of this study was to evaluate COVID-19 morbidity and mortality in patients with pre-existing thyroid dysfunction. A retrospective cohort of patients with a polymerase chain reaction (PCR)-con?rmed COVID-19 infection (n=14 966) from March 11 to May 30, 2020, was established using the database of the Turkish Ministry of Health. We compared the morbidity and mortality rates of COVID-19 patients with pre-existing hypothyroidism (n=8813) and hyperthyroidism (n=1822) to those patients with normal thyroid function (n=4331). Univariate and multivariate regression analyses were performed to identify the factors associated with mortality. Mortality rates were higher in patients with hyperthyroidism (7.7%) and hypothyroidism (4.4%) than those with normal thyroid function (3.4%) (p < 0.001 and p=0.008, respectively). Pre-existing hyperthyroidism was significantly associated with an increased risk of mortality (OR 1.54; 95% CI, 1.02-2.33; p=0.042) along with advanced age, male gender, lymphopenia and chronic kidney disease (p < 0.001 for all). Although a potential trend was noted, the association between pre-existing hypothyroidism and mortality was not significant (OR 1.36; 95% CI, 0.99-1.86; p=0.055). In conclusion, this study showed an association between pre-existing hyperthyroidism with higher COVID-19 mortality. A potential trend towards increased mortality was also observed for hypothyroidism. The risk was more pronounced in patients with hyperthyroidism.en_US
dc.identifier.doi10.1055/a-1971-8781
dc.identifier.endpage30en_US
dc.identifier.issn0018-5043
dc.identifier.issn1439-4286
dc.identifier.issue1en_US
dc.identifier.pmid36328149en_US
dc.identifier.scopus2-s2.0-85143122395en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage25en_US
dc.identifier.urihttps://doi.org/10.1055/a-1971-8781
dc.identifier.urihttps://hdl.handle.net/11616/101029
dc.identifier.volume55en_US
dc.identifier.wosWOS:000896686600003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofHormone and Metabolic Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectthyroid dysfunctionen_US
dc.subjecthyperthyroidismen_US
dc.subjectTSHen_US
dc.subjectCOVID-19en_US
dc.subjectmortalityen_US
dc.subjectICU admissionen_US
dc.titleThe Clinical Characteristics and Outcomes of COVID-19 Patients with Pre-Existing Thyroid Dysfunction: A Nationwide Studyen_US
dc.typeArticleen_US

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