Dietary arginine silicate inositol complex inhibits periodontal tissue loss in rats with ligature-induced periodontitis

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dc.authoridAkdemir, Fatih/0000-0002-5779-6631
dc.authoridSahin, Kazim/0000-0001-9542-5244
dc.authoridÖZERCAN, ibrahim Hanifi/0000-0002-8781-8838
dc.authoriduslu, mustafa özay/0000-0002-9707-1379
dc.authoridTuzcu, Mehmet/0000-0002-1329-3143
dc.authorwosidAkdemir, Fatih/AAG-8010-2019
dc.authorwosidSahin, Kazim/D-5625-2009
dc.authorwosidÖZERCAN, ibrahim Hanifi/W-7883-2018
dc.authorwosidDundar, Serkan/V-8159-2018
dc.authorwosiduslu, mustafa özay/S-7657-2019
dc.authorwosidTuzcu, Mehmet/H-2953-2018
dc.contributor.authorDundar, Serkan
dc.contributor.authorEltas, Abubekir
dc.contributor.authorHakki, Ema S.
dc.contributor.authorMalkoc, Siddik
dc.contributor.authorUslu, M. Ozay
dc.contributor.authorTuzcu, Mehmet
dc.contributor.authorKomorowski, James
dc.date.accessioned2024-08-04T20:42:51Z
dc.date.available2024-08-04T20:42:51Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe purpose of this study was to induce experimental periodontitis in rats previously fed diets containing arginine silicate inositol (ASI) complex and examine the biochemical, immunological, and radiological effects. Fifty two 8-week-old female Sprague Dawley rats were equally divided into four groups. The control group included those fed a standard rat diet with no operation performed during the experiment. The periodontitis, ASI I, and ASI II groups were subjected to experimental periodontitis induction for 11 days after being fed a standard rat diet alone, a diet containing 1.81 g/kg ASI complex, or a diet containing 3.62 g/kg ASI complex, respectively, for 8 weeks. Throughout the 11-day duration of periodontitis induction, all rats were fed standard feed. The rats were euthanized on the eleventh day, and their tissue and blood samples were collected. In the periodontitis group, elevated tissue destruction parameters and reduced tissue formation parameters were found, as compared to the ASI groups. Levels of enzymes, cytokines, and mediators associated with periodontal tissue destruction were lower in rats fed a diet containing ASI complex after experimental periodontitis. These results indicate that ASI complex could be an alternative agent for host modulation.en_US
dc.description.sponsorshipScientific Research Project Fund of Inonu University [2013/88]; Turkish Academy of Sciencesen_US
dc.description.sponsorshipWe thank Nurhan Sahin and Cemal Orhan for their collaboration in our experiments. This work was supported by the Scientific Research Project Fund of Inonu University under project number 2013/88 and the Turkish Academy of Sciences (to KS).en_US
dc.identifier.doi10.2147/DDDT.S115088
dc.identifier.endpage3778en_US
dc.identifier.issn1177-8881
dc.identifier.pmid27895467en_US
dc.identifier.scopus2-s2.0-85003506467en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage3771en_US
dc.identifier.urihttps://doi.org/10.2147/DDDT.S115088
dc.identifier.urihttps://hdl.handle.net/11616/97622
dc.identifier.volume10en_US
dc.identifier.wosWOS:000387822300002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherDove Medical Press Ltden_US
dc.relation.ispartofDrug Design Development and Therapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectarginine silicate inositol complexen_US
dc.subjectexperimental periodontitisen_US
dc.subjecthost modulationen_US
dc.subjectmicro-computed tomographyen_US
dc.subjectperiodontal infectionen_US
dc.titleDietary arginine silicate inositol complex inhibits periodontal tissue loss in rats with ligature-induced periodontitisen_US
dc.typeArticleen_US

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