Hypertonic saline in hydatid disease

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dc.authoridKayaalp, Cuneyt/0000-0003-4657-2998
dc.authorwosidBALKAN, SALİH MUJDAT/ABI-5250-2020
dc.authorwosidKayaalp, Cuneyt/AAH-1764-2021
dc.contributor.authorKayaalp, C
dc.contributor.authorBalkan, M
dc.contributor.authorAydin, C
dc.contributor.authorOzgurtas, T
dc.contributor.authorTanyuksel, M
dc.contributor.authorKirimlioglu, V
dc.contributor.authorAkoglu, M
dc.date.accessioned2024-08-04T20:12:13Z
dc.date.available2024-08-04T20:12:13Z
dc.date.issued2001
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe objective of this study was to determine the scolicidal effects of saline in different concentrations using different exposure times and to examine whether hypertonic saline can be used to irrigate the abdomen when there is a free intraperitoneal perforation of hydatid disease. Various concentrations of saline solutions (0.09%, 3.0%, 6.5%, 10%, 15%, 20%, 25%, 30%) were added to concentrated echinococcus granulosus sediments for the following times: 1, 2, 3, 4, 5, 10, 15, 30, 45, and 60 minutes. Normal (0.09%), 3.0%, and 6.5% saline resulted in high viability ratios after 60 minutes' exposure. Complete lethality for 10%, 15%, 20%, 25%, and 30% saline occurred at the end of 75, 10, 6, 3, and 3 minutes, respectively. During the second part of the study, 20 Sprague-Dawley rats were used for abdominal saline irrigation in four groups: 30% NaCl for 3 minutes; 20% NaCl for 6 minutes; intravenous isotonic dextrose water and furosemide plus 30% NaCl irrigation for 3 minutes; the same prophylactic therapy plus 20% NaCl irrigation for 6 minutes. Sodium and chloride values rose significantly (20-30%) shortly after hypertonic saline irrigation in each group (p < 0.01). Support with isotonic dextrose and furosemide before irrigation did not have any beneficial effect on biochemical values or mortality. The 24- and 48-hour mortality rates were 70% and 90%, respectively. These studies illustrate that the scolicidal effect of hypertonic saline is limited in low concentrations, but an increase in the concentration can augment its adverse effects. Peritoneal irrigation with hypertonic saline should be avoided for intraabdominal perforated hydatid disease. Therefore, we concluded that hypertonic saline is not a good scolicidal agent to prevent recurrence of hydatid disease.en_US
dc.identifier.doi10.1007/s00268-001-0065-9
dc.identifier.endpage979en_US
dc.identifier.issn0364-2313
dc.identifier.issn1432-2323
dc.identifier.issue8en_US
dc.identifier.pmid11571978en_US
dc.identifier.scopus2-s2.0-0034884934en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage975en_US
dc.identifier.urihttps://doi.org/10.1007/s00268-001-0065-9
dc.identifier.urihttps://hdl.handle.net/11616/93292
dc.identifier.volume25en_US
dc.identifier.wosWOS:000170337300002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofWorld Journal of Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLiveren_US
dc.subjectCystsen_US
dc.titleHypertonic saline in hydatid diseaseen_US
dc.typeArticleen_US

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