Comparison of dialysate and plasma NTproBNP in prediction of clinical outcomes of diabetic and nondiabetic peritoneal dialysis patients

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dc.authoridSahin, Idris/0000-0002-8683-3737
dc.authoridKoz, Sema T/0000-0002-6342-0200
dc.authorwosidSahin, Idris/AAS-4390-2020
dc.authorwosidKoz, Sema T/AAS-3664-2021
dc.contributor.authorKoz, Suleyman
dc.contributor.authorSahin, Idris
dc.contributor.authorKayatas, Mansur
dc.contributor.authorKoz, Sema Tulay
dc.date.accessioned2024-08-04T20:44:35Z
dc.date.available2024-08-04T20:44:35Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Plasma level of N-terminal pro-brain natriuretic peptide (P-NTproBNP) is a useful marker in prediction of mortality in peritoneal dialysis (PD) patients. However, the predictive value of spent dialysate counterpart (D-NTproBNP) of plasma NTproBNP on mortality and dropout is not known. Materials and methods: Simultaneous P-NTproBNP and D-NTproBNP assays were performed after an overnight dwell in 44 scheduled ambulatory PD patients. Patients were followed for similar to 47 months. Deceased patients or patients who were transferred to hemodialysis were regarded as dropouts. Results: 14 patients (31.8%) dropped out at similar to 4 years (9 deaths and 5 transfers to hemodialysis). Diabetics, males, and patients with higher membrane permeability had higher dropout rates. Patients with P-and D-NTproBNP higher than median values had higher mortality and dropout rates (Kaplan-Meier test, log-rank Test p < 0.05). Odds ratios of D-NTproBNP for death and dropouts were (3.807 (0.907-15.971), p = 0.068) and (2.87 (1.009-8.138) p = 0.048), respectively; odds ratios of P-NTproBNP for death and dropouts were (4.652 (0.914-23.693), p = 0.064) and (2.67 (0.924-7.716), p = 0.07), respectively; in ROC analysis for death, AUC for P-and D-NTproBNP were 0.762 (0.578-0.946, p = 0.016) and 0.765 (0.590-0.940, p = 0.015), respectively. Exclusion of diabetic patients from the analyses resulted in significant changes in the predictive value P-and D-NTproBNP. Although death and dropout rates were still higher in nondiabetic patients with higher NTproBNP levels, the differences between groups lost statistical significance. Conclusion: Both P-NTproBNP and D-NTproBNP are significant predictors of outcomes of interest. Predictive value of NTproBNP might be different in diabetics and non-diabetic CAPD patients.en_US
dc.description.sponsorshipInonu University (INUBAP) [2012/97]en_US
dc.description.sponsorshipThe study was conducted through a grant obtained from Inonu University (INUBAP, Project No: 2012/97).en_US
dc.identifier.doi10.5414/CN109139
dc.identifier.endpage33en_US
dc.identifier.issn0301-0430
dc.identifier.issue1en_US
dc.identifier.pmid29350172en_US
dc.identifier.scopus2-s2.0-85048498500en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage27en_US
dc.identifier.urihttps://doi.org/10.5414/CN109139
dc.identifier.urihttps://hdl.handle.net/11616/98337
dc.identifier.volume90en_US
dc.identifier.wosWOS:000435373000005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherDustri-Verlag Dr Karl Feistleen_US
dc.relation.ispartofClinical Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectperitoneal dialysisen_US
dc.subjectdialysate NTproBNPen_US
dc.subjectnatriuretic peptideen_US
dc.subjectNTproBNP and diabetesen_US
dc.subjectmortalityen_US
dc.subjectdropouten_US
dc.titleComparison of dialysate and plasma NTproBNP in prediction of clinical outcomes of diabetic and nondiabetic peritoneal dialysis patientsen_US
dc.typeArticleen_US

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