Evaluation of tumor angiogenesis with contrast-enhanced dynamic magnetic resonance mammography

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dc.authorscopusid56020521100
dc.authorscopusid56214353000
dc.authorscopusid6603854521
dc.authorscopusid35564549100
dc.authorscopusid6603160202
dc.contributor.authorTuncbilek N.
dc.contributor.authorUnlu E.
dc.contributor.authorKarakas H.M.
dc.contributor.authorCakir B.
dc.contributor.authorOzyilmaz F.
dc.date.accessioned2024-08-04T20:00:46Z
dc.date.available2024-08-04T20:00:46Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe goal of this research was to correlate dynamic magnetic resonance (MR) mammographic contrast enhancement and microvessel densities in breast masses. Forty-six female patients with breast masses detected by mammography and/or ultrasonography were included in the study. MR contrast enhancements of the lesions were investigated dynamically using axial three-dimensional fast low-angle shot sequences. After excisional biopsy or mastectomy, immunohistochemical staining with factor VIII-RA was performed, followed by microvessel density measurements. Contrast enhancement patterns in dynamic MR mammography were compared with microvessel density measurements using Student's t-test, Pearson's moment correlation coefficients, and one-way analysis of variance (ANOVA). Malignant lesions exhibited three different enhancement patterns: 1) a peak enhancement within 120 seconds (early phase), followed by a decrease in the delayed phase (25 cases); 2) an increase in the early phase, followed by a plateau in the delayed phase (9 cases); and 3) an increase throughout the examination without any peak (5 cases). In benign lesions, signal intensity did not exhibited a peak in five cases, whereas in two cases enhancement was increased in the early phase and made a plateau in the delayed phase. A significant correlation was found between microvessel density and the percentage of maximal signal increase following paramagnetic contrast administration (r= 0.322, p < 0.05). Dynamic enhancement patterns and rates of maximal signal increase predict microvessel density in breast malignancies and may possibly be used as prognostic indicators.en_US
dc.identifier.doi10.1046/j.1524-4741.2003.09508.x
dc.identifier.endpage408en_US
dc.identifier.issn1075-122X
dc.identifier.issue5en_US
dc.identifier.pmid12968962en_US
dc.identifier.scopus2-s2.0-0141567069en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage403en_US
dc.identifier.urihttps://doi.org/10.1046/j.1524-4741.2003.09508.x
dc.identifier.urihttps://hdl.handle.net/11616/90989
dc.identifier.volume9en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofBreast Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAngiogenesisen_US
dc.subjectBreast canceren_US
dc.subjectDynamic MR mammographyen_US
dc.subjectMicrovessel densityen_US
dc.titleEvaluation of tumor angiogenesis with contrast-enhanced dynamic magnetic resonance mammographyen_US
dc.typeArticleen_US

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