Administration of MINE protocol in untreated patients with intermediate and high grade non-Hodgkin's lymphoma

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dc.authoridGURMAN, Gunhan/0000-0002-1263-8947
dc.authoridBeksac, Meral/0000-0003-1797-8657
dc.authorwosidGURMAN, Gunhan/AAM-8863-2020
dc.authorwosidBeksac, Meral/D-6411-2013
dc.contributor.authorAydogdu, I
dc.contributor.authorKoc, H
dc.contributor.authorIlhan, O
dc.contributor.authorGurman, G
dc.contributor.authorAkan, H
dc.contributor.authorBeksac, M
dc.contributor.authorKonuk, N
dc.date.accessioned2024-08-04T20:11:57Z
dc.date.available2024-08-04T20:11:57Z
dc.date.issued1997
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn recent years, more effective and less toxic treatment protocols have been developed to increase the cure rates in intermediate and high grade non-Hodgkin's lymphoma (NHL). This study was undertaken to investigate the efficacy and toxicity of MWE (ifosfamide, mesna, mitoxantrone and etoposide) combination chemotherapy in patients with intermediate and high grade NHL. Twenty-one patients (16 male, 5 female; age between 26 and 70 years) with NHL were included in the study. An overall response rate of 73% and complete response rate of 56% were achieved and survival rate for responding patients was 80% at the 48th month. Side effects including mild myelosuppression, nausea/vomiting and alopecia were observed. MINE combination seems to be effective and well tolerated without significant toxicity as a first-line therapy in patients with intermediate or high grade NHL.en_US
dc.identifier.endpage213en_US
dc.identifier.issn0017-6559
dc.identifier.issue4en_US
dc.identifier.pmid9408764en_US
dc.identifier.scopus2-s2.0-0031464921en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage207en_US
dc.identifier.urihttps://hdl.handle.net/11616/93097
dc.identifier.volume28en_US
dc.identifier.wosWOS:A1997YK20900003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVsp Bven_US
dc.relation.ispartofHaematologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectnon-Hodgkin's lymphomaen_US
dc.subjectcombination chemotherapyen_US
dc.subjectifosfamideen_US
dc.subjectmitoxantroneen_US
dc.titleAdministration of MINE protocol in untreated patients with intermediate and high grade non-Hodgkin's lymphomaen_US
dc.typeArticleen_US

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