Genotoxicity testing of tributyltin and methidathion in drosophila melanogaster using the wing somatic mutation and recombination test

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dc.authorscopusid56594578100
dc.authorscopusid55565378700
dc.contributor.authorKarabulut A.K.
dc.contributor.authorYesilada E.
dc.date.accessioned2024-08-04T20:00:39Z
dc.date.available2024-08-04T20:00:39Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, genotoxic effects of tributyltin (TBT) and methidathion (MD) were investigated using Drosophila wing somatic mutation and recombination test (SMART). This test is based on the principle that the loss of heterozygosity of suitable recessive marker hairs such as multiple wing (mwh) and flare-3 (flr3), can lead to the formation of mutant clones of larval cells, which are then expressed as spots on the wings of the adult flies. Third-instar larvae that were trans-heterozygous for the two genetic markers mwh and flr3 were treated at different doses (0,1 mg/L, 1 mg/L, 10 mg/L, 30 mg/L, and 50 mg/L of TBT and 0.01 mg/L, 0.025 mg/L, 0.05 mg/L, 0.06 mg/L, and 0.075 mg/L of MD) of the test compounds. Mitomycin C (MMC), a commonly known mutagen, was used as positive control. The results indicated that highest experimental dose of TBT showed toxic and genotoxic effects, including recombinogenic activity in the marker-heterozygous flies. However, based on our results, MD showed no genotoxicity in the SMART assay, an in vivo model.en_US
dc.identifier.endpage3480en_US
dc.identifier.issn1018-4619
dc.identifier.issue12Cen_US
dc.identifier.scopus2-s2.0-84927720982en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage3475en_US
dc.identifier.urihttps://hdl.handle.net/11616/90903
dc.identifier.volume23en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherParlar Scientific Publicationsen_US
dc.relation.ispartofFresenius Environmental Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDrosophila melanogasteren_US
dc.subjectGenotoxicityen_US
dc.subjectMethidathion (MD)en_US
dc.subjectMitomycin-C (MMC)en_US
dc.subjectSMARTen_US
dc.subjectTributyltin (TBT)en_US
dc.titleGenotoxicity testing of tributyltin and methidathion in drosophila melanogaster using the wing somatic mutation and recombination testen_US
dc.typeArticleen_US

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