Adrenomedullin has a role in angiogenic effects of resveratrol in adipose tissues of obese female rats

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dc.authoridCulum, Ayse Asiye/0000-0002-0072-7600
dc.authoridYurekli, Muhittin/0000-0002-5830-8564
dc.authorwosidCulum, Ayse Asiye/HLG-6685-2023
dc.authorwosidYurekli, Muhittin/B-4414-2016
dc.contributor.authorCulum, Ayse Asiye
dc.contributor.authorYurekli, Muhittin
dc.date.accessioned2024-08-04T20:47:04Z
dc.date.available2024-08-04T20:47:04Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObesity is a complex, chronic disease that arises according to the interaction between genetic and environmental factors. The expansion and growth of white adipose tissue (WAT) could be related to angiogenesis. Resveratrol and adrenomedullin (AdM) were used for the inhibition of angiogenesis in metabolically passive WAT for inhibiting the expansion of this tissue, and the activation of angiogenesis in metabolically active brown adipose tissue (BAT) for increasing daily energy consumption as a way of reducing obesity. Rats were divided into eight groups. Four obese groups were fed with a high-fat diet containing 60% fat as energy for three months. After obtaining obesity, 2.5 nmol/kg AdM and 10 mg/kg resveratrol were treated to experiment groups intraperitoneally (i.p.) every other day for four weeks. AdM and vascular endothelial growth factor A (VEGF-A) mRNA levels were detected with semi-quantitative PCR; protein levels were detected with Western Blotting. AdM and resveratrol are multifactorial molecules, thus, this study has revealed a few novel evidence. The results were distinct in the group and treatment levels. The results showed that resveratrol has a role in angiogenesis in obesity and contributed to AdM production. It is observed that AdM has regulated its expression and increased the effect of resveratrol in WAT. AdM and VEGF-A gene expressions could not be detected in BAT; however, it is suggested that resveratrol may have a pro-angiogenic effect in BAT of obese rats according to the protein levels. AdM also has regulated VEGF-A level according to the metabolic situation of the organism.en_US
dc.description.sponsorshipInonu University, Department of Scientific Research Projects [2016/153] Funding Source: Medlineen_US
dc.identifier.doi10.1007/s11033-020-05256-2
dc.identifier.endpage1680en_US
dc.identifier.issn0301-4851
dc.identifier.issn1573-4978
dc.identifier.issue3en_US
dc.identifier.pmid31933262en_US
dc.identifier.scopus2-s2.0-85077910791en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1667en_US
dc.identifier.urihttps://doi.org/10.1007/s11033-020-05256-2
dc.identifier.urihttps://hdl.handle.net/11616/99145
dc.identifier.volume47en_US
dc.identifier.wosWOS:000527853900012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofMolecular Biology Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectObesityen_US
dc.subjectVEGF-Aen_US
dc.subjectAdrenomedullinen_US
dc.subjectResveratrolen_US
dc.subjectBrown adipose tissueen_US
dc.subjectWhite adipose tissueen_US
dc.titleAdrenomedullin has a role in angiogenic effects of resveratrol in adipose tissues of obese female ratsen_US
dc.typeArticleen_US

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