Is there any role of Toxoplasma gondii in the etiology of obsessive-compulsive disorder?

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dc.authoridKarlıdağ, Rifat/0000-0002-3650-0774
dc.authoridUnal, Suheyla/0000-0003-3266-6256
dc.authoridUnal, Suheyla/0000-0003-3266-6256
dc.authoridÖzcan, Özlem/0000-0003-3267-2648
dc.authoridMutlu, Elif Aktan/0000-0002-0889-1421
dc.authorwosidKarlıdağ, Rifat/AAB-4281-2021
dc.authorwosidkarlıdağ, rıfat/AAB-4255-2021
dc.authorwosidUnal, Suheyla/HJH-7559-2023
dc.authorwosidUnal, Suheyla/JVO-8367-2024
dc.authorwosidÖzcan, Özlem/ABH-9167-2020
dc.authorwosidUnal, Suheyla/AAS-2388-2020
dc.authorwosidMutlu, Elif Aktan/AAE-9609-2021
dc.contributor.authorMiman, Ozlem
dc.contributor.authorMutlu, Elif Aktan
dc.contributor.authorOzcan, Ozlem
dc.contributor.authorAtambay, Metin
dc.contributor.authorKarlidag, Rifat
dc.contributor.authorUnal, Suheyla
dc.date.accessioned2024-08-04T20:32:23Z
dc.date.available2024-08-04T20:32:23Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObsessive-compulsive disorder (OCD) is a common psychiatric illness. Although the aetiology of OCD is still unknown, the family-genetic data show that familial forms of OCD may be associated with a specific genetic susceptibility. Recent investigations have associated development of OCD with infectious illness. Toxoplasmic encephalitis (TE) is a common presentation of Toxoplasma gondii infection of the central nervous system (CNS). The most commonly affected CNS region in TE is the cerebral hemisphere, followed by the basal ganglia, cerebellum and brain stem. The basal ganglia has been implicated in the development of OCD. Therefore, in this study, it was aimed to investigate a possible association between Toxoplasma infection and OCD. We selected 42 patients with OCD and 100 healthy volunteers, and investigated the sero-positivity rate for anti-Toxoplasma IgG antibodies by Enzyme Linked Immunosorbent Assay (ELISA). The sero-positivity rate for anti-T. gondii IgG antibodies among OCD patients (47.62%) was found to be significantly higher than the rate in healthy volunteers (19%). This is the first report to examine a potential association between Toxoplasma infection and OCD. The main finding of the present study is an increased level of IgG antibodies to T. gondii in OCD patients when compared with the level in healthy controls. There might be a causal relationship between chronic toxoplasmosis and the aetiology of OCD. (C) 2010 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.psychres.2009.12.013
dc.identifier.endpage265en_US
dc.identifier.issn0165-1781
dc.identifier.issue1-2en_US
dc.identifier.pmid20106536en_US
dc.identifier.scopus2-s2.0-77952090141en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage263en_US
dc.identifier.urihttps://doi.org/10.1016/j.psychres.2009.12.013
dc.identifier.urihttps://hdl.handle.net/11616/95030
dc.identifier.volume177en_US
dc.identifier.wosWOS:000278278800048en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofPsychiatry Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectToxoplasma gondiien_US
dc.subjectObsessive-compulsive disorder (OCD)en_US
dc.subjectBasal gangliaen_US
dc.subjectELISAen_US
dc.titleIs there any role of Toxoplasma gondii in the etiology of obsessive-compulsive disorder?en_US
dc.typeArticleen_US

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