A clinical pharmacist's intervention on interaction between meropenem and valproic acid in paediatric inpatient clinic: A case report

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dc.authoridMemiş, Hasan/0000-0001-7158-1795
dc.authoridÇakır, Ahmet/0000-0002-9843-1604
dc.authoridÖzdemir, Nesligül/0000-0003-2551-9549
dc.authorwosidMemiş, Hasan/AAA-9596-2022
dc.authorwosidÇakır, Ahmet/ABH-5565-2020
dc.authorwosidÖzdemir, Nesligül/ABH-5503-2020
dc.contributor.authorCakir, Ahmet
dc.contributor.authorMemis, Hasan
dc.contributor.authorOzdemir, Nesligul
dc.contributor.authorGun, Zeynep Ulku
dc.date.accessioned2024-08-04T20:11:42Z
dc.date.available2024-08-04T20:11:42Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and Aims: Drug-drug interactions cause many complex drug events, especially adverse drug effects. It is known that drug interactions occur when meropenem and valproic acid are used together. It was aimed to back up existing research on the interaction of valproic acid. Methods: After an interaction had been suspected by the ward pharmacists, all of the patient's drugs were assessed via UpToDate (R) and Micromedex (R) databases and the interaction management was shared with the physician in charge. Results: The patient's serum valproic acid through level was in therapeutic range before meropenem administration. After the administration of meropenem, the patient's number of seizures increased and the serum trough level of valproic acid decreased to 4.3 mu g/ml. The valproic acid levels turned back to normal range after switching to a carbapenem antibiotic. Conclusion: Drug interactions are often encountered in paediatric patients and it is of critical importance in terms of seizure control. Because of the drug interaction between valproic acid and meropenem, one should avoid using these medications concomitantly. If that is impossible, daily serum valproic acid levels should be monitored with caution. Clinical pharmacists could increase the clinicians' awareness about drug-drug interactions.en_US
dc.identifier.doi10.26650/IstanbulJPharm.2023.1202590
dc.identifier.endpage94en_US
dc.identifier.issn2587-2087
dc.identifier.issue1en_US
dc.identifier.startpage92en_US
dc.identifier.trdizinid1177021en_US
dc.identifier.urihttps://doi.org/10.26650/IstanbulJPharm.2023.1202590
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1177021
dc.identifier.urihttps://hdl.handle.net/11616/92925
dc.identifier.volume53en_US
dc.identifier.wosWOS:000995958300013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherIstanbul Univ, Fac Pharmacyen_US
dc.relation.ispartofIstanbul Journal of Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDrug interactionsen_US
dc.subjecthospitalized childen_US
dc.subjectmeropenemen_US
dc.subjectclinical pharmacistsen_US
dc.subjectvalproic aciden_US
dc.titleA clinical pharmacist's intervention on interaction between meropenem and valproic acid in paediatric inpatient clinic: A case reporten_US
dc.typeArticleen_US

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