Protective effect of aminoguanidine against nephrotoxicity induced by amikacin in rats

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dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridAcet, Ahmet/0000-0003-1131-1878
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.authorwosidPolat, Alaadin/Q-4052-2018
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidAcet, Ahmet/AAB-3273-2021
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.contributor.authorParlakpinar, H
dc.contributor.authorKoc, M
dc.contributor.authorPolat, A
dc.contributor.authorVardi, N
dc.contributor.authorOzer, MK
dc.contributor.authorTurkoz, Y
dc.contributor.authorAcet, A
dc.date.accessioned2024-08-04T20:30:51Z
dc.date.available2024-08-04T20:30:51Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAminoglycoside antibiotics have long been used in antibacterial therapy. Despite their beneficial effects, aminoglycosides have considerable nephrotoxic and ototoxic side effects. It has been reported that reactive oxygen radical species (ROS) play role in the pathophysiology of aminoglycosides-induced nephrotoxicity. Aminoguanidine (AG) is an effective antioxidant and free radical scavenger which has long been known to protect against nephrotoxicity. We investigated the effects of AG on amikacin (AK)-induced changes of renal malondialdehyde (MDA), glutathione (GSH), blood urea nitrogen (BUN), serum creatinine (Cr) and albumin (Alb) which are used to monitor the development of renal tubular damage. Morphological changes in the kidney were also examined using light microscopy. A total of 21 rats were equally divided into three groups which were: (1) injected with saline, (2) injected with AK, and (3) injected with AK + AG, respectively. AK administration to control rats increased renal MDA and decreased GSH levels. AG administration before AK injection caused significant decreases in MDA and increases in GSH levels in kidneys compared to rats treated with AK alone. The serum BUN level increased slightly, Cr and serum Alb did not change as a result of any treatment. AG tended to decrease the level of serum BUN and did not cause any change in Alb or Cr levels. Morphological changes, including glomerular, tubular epithelial alterations and interstitial edema, were clearly observed in AK-treated rats. In addition, AG reversed the morphological damage to the kidney induced by AK. The results show that AG has a protective effect on nephrotoxicity induced by AK and may therefore improve the therapeutic index of AK.en_US
dc.identifier.doi10.1007/s00240-004-0399-5
dc.identifier.endpage282en_US
dc.identifier.issn0300-5623
dc.identifier.issue4en_US
dc.identifier.pmid15278326en_US
dc.identifier.scopus2-s2.0-4544383616en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage278en_US
dc.identifier.urihttps://doi.org/10.1007/s00240-004-0399-5
dc.identifier.urihttps://hdl.handle.net/11616/94574
dc.identifier.volume32en_US
dc.identifier.wosWOS:000223373300004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofUrological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectamikacinen_US
dc.subjectaminoguanidineen_US
dc.subjectmalondialdehydeen_US
dc.subjectrenal injuryen_US
dc.subjectraten_US
dc.titleProtective effect of aminoguanidine against nephrotoxicity induced by amikacin in ratsen_US
dc.typeArticleen_US

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