Hesperidin Mitigates Bleomycin-Induced Testicular and Spermatological Damage in Rats

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dc.contributor.authorAyhan, Idris
dc.contributor.authorTurkmen, Nese Basak
dc.contributor.authorAlan, Saadet
dc.contributor.authorAydin, Muhterem
dc.contributor.authorCiftci, Osman
dc.date.accessioned2026-04-04T13:33:23Z
dc.date.available2026-04-04T13:33:23Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractBleomycin (BLM), a chemotherapeutic agent commonly used in cancer treatment, is associated with oxidative stress and testicular toxicity, leading to impaired reproductive health. Hesperidin (HES), a citrus-derived flavonoid with strong antioxidant properties, has the potential to counteract these adverse effects. This study aimed to evaluate the protective effects of HES against the reproductive toxicity induced by BLM, focusing on oxidative stress, sperm characteristics and histological changes in the male reproductive system. Thirty-two rats were divided into four groups: Control, BLM, HES and BLM + HES. BLM was administered intraperitoneally at 10 mg/kg twice a week, while HES was given orally at 50 mg/kg/day for 30 days. The findings revealed that BLM induced significant oxidative stress by promoting lipid peroxidation and impairing antioxidant defence mechanisms in the testis. Additionally, BLM treatment caused a marked decline in sperm motility, an increase in abnormal sperm rates and severe histopathological damage in testicular tissue. However, co-administration of HES significantly mitigated these adverse effects by improving oxidative balance, restoring sperm quality and reducing histopathological injuries. In conclusion, HES demonstrated potential in alleviating BLM-induced reproductive toxicity, suggesting its therapeutic role in protecting against chemotherapy-induced male infertility.
dc.identifier.doi10.1111/bcpt.70119
dc.identifier.issn1742-7835
dc.identifier.issn1742-7843
dc.identifier.issue4
dc.identifier.orcid0000-0003-4625-7218
dc.identifier.orcid0000-0003-2329-151X
dc.identifier.orcid0000-0001-5755-3560
dc.identifier.pmid40985279
dc.identifier.scopus2-s2.0-105016769606
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1111/bcpt.70119
dc.identifier.urihttps://hdl.handle.net/11616/109112
dc.identifier.volume137
dc.identifier.wosWOS:001586607400004
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofBasic & Clinical Pharmacology & Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectbleomycin
dc.subjecthesperidin
dc.subjectoncofertility
dc.subjectoxidative stress
dc.subjectsperm motility
dc.subjecttesticular damage
dc.titleHesperidin Mitigates Bleomycin-Induced Testicular and Spermatological Damage in Rats
dc.typeArticle

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